Literature DB >> 25715179

Sirtuin inhibitor sirtinol is an intracellular iron chelator.

R Gautam1, E A Akam, A V Astashkin, J J Loughrey, E Tomat.   

Abstract

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.

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Year:  2015        PMID： 25715179      PMCID： PMC4355247          DOI： 10.1039/c5cc00829h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  34 in total

1.  SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

Authors:  Barrie Peck; Chun-Yuan Chen; Ka-Kei Ho; Paolo Di Fruscia; Stephen S Myatt; R Charles Coombes; Matthew J Fuchter; Chwan-Deng Hsiao; Eric W-F Lam
Journal:  Mol Cancer Ther       Date:  2010-04-06       Impact factor: 6.261

2.  Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.

Authors:  Sung-Jun Park; Faiyaz Ahmad; Andrew Philp; Keith Baar; Tishan Williams; Haibin Luo; Hengming Ke; Holger Rehmann; Ronald Taussig; Alexandra L Brown; Myung K Kim; Michael A Beaven; Alex B Burgin; Vincent Manganiello; Jay H Chung
Journal:  Cell       Date:  2012-02-03       Impact factor: 41.582

3.  Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

Authors:  Antonello Mai; Silvio Massa; Siva Lavu; Riccardo Pezzi; Silvia Simeoni; Rino Ragno; Francesca R Mariotti; Francesco Chiani; Giorgio Camilloni; David A Sinclair
Journal:  J Med Chem       Date:  2005-12-01       Impact factor: 7.446

4.  New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

Authors:  Jonathan B Baell; Georgina A Holloway
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

Review 5.  Structural basis for sirtuin activity and inhibition.

Authors:  Hua Yuan; Ronen Marmorstein
Journal:  J Biol Chem       Date:  2012-10-18       Impact factor: 5.157

6.  Chemistry: Chemical con artists foil drug discovery.

Authors:  Jonathan Baell; Michael A Walters
Journal:  Nature       Date:  2014-09-25       Impact factor: 49.962

Review 7.  Sirtuins as regulators of metabolism and healthspan.

Authors:  Riekelt H Houtkooper; Eija Pirinen; Johan Auwerx
Journal:  Nat Rev Mol Cell Biol       Date:  2012-03-07       Impact factor: 94.444

8.  Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Authors:  Basil P Hubbard; Ana P Gomes; Han Dai; Jun Li; April W Case; Thomas Considine; Thomas V Riera; Jessica E Lee; Sook Yen E; Dudley W Lamming; Bradley L Pentelute; Eli R Schuman; Linda A Stevens; Alvin J Y Ling; Sean M Armour; Shaday Michan; Huizhen Zhao; Yong Jiang; Sharon M Sweitzer; Charles A Blum; Jeremy S Disch; Pui Yee Ng; Konrad T Howitz; Anabela P Rolo; Yoshitomo Hamuro; Joel Moss; Robert B Perni; James L Ellis; George P Vlasuk; David A Sinclair
Journal:  Science       Date:  2013-03-08       Impact factor: 47.728

Review 9.  Sorting out functions of sirtuins in cancer.

Authors:  M Roth; W Y Chen
Journal:  Oncogene       Date:  2013-04-22       Impact factor: 9.867

10.  SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Authors:  Michelle Pacholec; John E Bleasdale; Boris Chrunyk; David Cunningham; Declan Flynn; Robert S Garofalo; David Griffith; Matt Griffor; Pat Loulakis; Brandon Pabst; Xiayang Qiu; Brian Stockman; Venkataraman Thanabal; Alison Varghese; Jessica Ward; Jane Withka; Kay Ahn
Journal:  J Biol Chem       Date:  2010-01-08       Impact factor: 5.157
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  3 in total

1.  Metal-binding effects of sirtuin inhibitor sirtinol.

Authors:  Eman A Akam; Ritika Gautam; Elisa Tomat
Journal:  Supramol Chem       Date:  2015-10-15       Impact factor: 1.688

Review 2.  Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization.

Authors:  Israel Rodríguez; Ritika Gautam; Arthur D Tinoco
Journal:  Biomimetics (Basel)       Date:  2020-12-30

3.  Procaspase-3-activating compound 1 stabilizes hypoxia-inducible factor 1α and induces DNA damage by sequestering ferrous iron.

Authors:  Feifei Li; Aili Wei; Lijuan Bu; Long Long; Wei Chen; Chen Wang; Changqi Zhao; Lili Wang
Journal:  Cell Death Dis       Date:  2018-10-04       Impact factor: 8.469
  3 in total

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