| Literature DB >> 25715096 |
Miguel O'Ryan1, Roberto Vidal, Felipe del Canto, Juan Carlos Salazar, David Montero.
Abstract
In Part II we discuss the following bacterial pathogens: Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic) and Campylobacter jejuni. In contrast to the enteric viruses and Vibrio cholerae discussed in Part I of this series, for the bacterial pathogens described here there is only one licensed vaccine, developed primarily for Vibrio cholerae and which provides moderate protection against enterotoxigenic E. coli (ETEC) (Dukoral(®)), as well as a few additional candidates in advanced stages of development for ETEC and one candidate for Shigella spp. Numerous vaccine candidates in earlier stages of development are discussed.Entities:
Keywords: CFU, colony-forming units; CFs, colonization factors; CT, cholera toxin; CT-B cholera toxin B subunit; Campylobacter; CtdB, cytolethal distending toxin subunit B; E. coli; EHEC; EPEC, enteropathogenic E. coli; ETEC; ETEC, enterotoxigenic E. coli; GEMS, Global enterics multicenter study; HUS, hemolytic uremic syndrome; IM, intramuscular; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; LEE, locus of enterocyte effacement; LPS, lipopolysaccharide; LT, heat labile toxin; LT-B; OMV, outer membrane vesicles; ST, heat stable toxin; STEC; STEC, shigatoxin producing E. coli; STh, human heat stable toxin; STp, porcine heat stable toxin; Salmonella; Shigella; Stx, shigatoxin; TTSS, type III secretion system; V. cholera; WHO, World Health Organization; acute diarrhea; dmLT, double mutant heat labile toxin; enteric pathogens; enterohemorrhagic E. coli; gastroenteritis; heat labile toxin B subunit; norovirus; rEPA, recombinant exoprotein A of Pseudomonas aeruginosa; rotavirus; vaccines
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Year: 2015 PMID： 25715096 PMCID： PMC4514228 DOI： 10.1080/21645515.2015.1011578
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN： 2164-5515 Impact factor: 3.452