Literature DB >> 25714803

mTOR and metabolic regulation of conventional and regulatory T cells.

Chaohong Liu1, Nicole M Chapman1, Peer W F Karmaus1, Hu Zeng1, Hongbo Chi2.   

Abstract

mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs In this review, we discuss the regulation of mTOR signaling in T cells and the functional impacts of mTOR and metabolic pathways on T cell-mediated immune responses, with a particular focus on the differentiation and function of Tregs. © Society for Leukocyte Biology.

Entities:  

Keywords:  T cell differentiation; Tregs; glycolysis; lipid; metabolism

Year:  2015        PMID： 25714803      PMCID： PMC4398256          DOI： 10.1189/jlb.2RI0814-408R

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  118 in total

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