Literature DB >> 25714652

Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle.

Phillip L van der Peet1, Christian Gunawan, Shota Torigoe, Sho Yamasaki, Spencer J Williams.   

Abstract

An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2'S-isomer.

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Year:  2015        PMID： 25714652     DOI： 10.1039/c5cc00085h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Engineering the Mycomembrane of Live Mycobacteria with an Expanded Set of Trehalose Monomycolate Analogues.

Authors:  Taylor J Fiolek; Nicholas Banahene; Herbert W Kavunja; Nathan J Holmes; Adrian K Rylski; Amol Arunrao Pohane; M Sloan Siegrist; Benjamin M Swarts
Journal:  Chembiochem       Date:  2019-03-18       Impact factor: 3.164

2.  Tailoring Trehalose for Biomedical and Biotechnological Applications.

Authors:  Mara K O'Neill; Brent F Piligian; Claire D Olson; Peter J Woodruff; Benjamin M Swarts
Journal:  Pure Appl Chem       Date:  2017-01-11       Impact factor: 2.453

3.  Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids.

Authors:  Judith Schick; Philipp Etschel; Rebeca Bailo; Lisa Ott; Apoorva Bhatt; Bernd Lepenies; Carsten Kirschning; Andreas Burkovski; Roland Lang
Journal:  Infect Immun       Date:  2017-06-20       Impact factor: 3.441

4.  Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.

Authors:  Masahiro Nagata; Yoshihiro Izumi; Eri Ishikawa; Ryoko Kiyotake; Rieko Doi; Satoru Iwai; Zakaria Omahdi; Toshiyuki Yamaji; Tomofumi Miyamoto; Takeshi Bamba; Sho Yamasaki
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-03       Impact factor: 11.205

5.  Rational design of adjuvants targeting the C-type lectin Mincle.

Authors:  Alexiane Decout; Sandro Silva-Gomes; Daniel Drocourt; Sophie Barbe; Isabelle André; Francisco J Cueto; Thierry Lioux; David Sancho; Eric Pérouzel; Alain Vercellone; Jacques Prandi; Martine Gilleron; Gérard Tiraby; Jérôme Nigou
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-21       Impact factor: 11.205

Review 6.  C-type lectin receptors in tuberculosis: what we know.

Authors:  Surabhi Goyal; Tilman E Klassert; Hortense Slevogt
Journal:  Med Microbiol Immunol       Date:  2016-07-28       Impact factor: 3.402

7.  Design of Trehalose-Based Amide/Sulfonamide C-type Lectin Receptor Signaling Compounds.

Authors:  Omer K Rasheed; Cassandra Buhl; Jay T Evans; Kendal T Ryter
Journal:  ChemMedChem       Date:  2021-02-09       Impact factor: 3.466

Review 8.  Sensing Lipids with Mincle: Structure and Function.

Authors:  Spencer J Williams
Journal:  Front Immunol       Date:  2017-11-27       Impact factor: 7.561

9.  Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.

Authors:  Alexandra Huber; Rie S Kallerup; Karen S Korsholm; Henrik Franzyk; Bernd Lepenies; Dennis Christensen; Camilla Foged; Roland Lang
Journal:  Innate Immun       Date:  2016-06-01       Impact factor: 2.680

Review 10.  Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands.

Authors:  Chriselle D Braganza; Thomas Teunissen; Mattie S M Timmer; Bridget L Stocker
Journal:  Front Immunol       Date:  2018-01-17       Impact factor: 7.561
  10 in total

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