Literature DB >> 25714613

The immune suppressive function of transforming growth factor-β (TGF-β) in human diseases.

Jingyi Sheng1, Weisan Chen, Hong-Jian Zhu.   

Abstract

Transforming growth factor-β (TGF-β) functions as an immune suppressor by influencing immune cells' development, differentiation, tolerance induction and homeostasis. In human diseases, TGF-β has been revealed as an essential regulator of both innate and adaptive functions in autoimmune diseases. Furthermore, it plays a significant role in cancer by inhibiting immunosurveillance in the tumor-bearing host. A variety of TGF-β neutralizing anti-cancer therapies have been investigated based on the role of TGF-β in immunosuppression. New studies are focusing on combining TGF-β blockade with tumor vaccinations and immunogene therapies.

Entities:  

Keywords:  Autoimmune diseases; TGF-β; cancer; immune suppression

Mesh：

Substances：

Year:  2015        PMID： 25714613     DOI： 10.3109/08977194.2015.1010645

Source DB:  PubMed          Journal:  Growth Factors        ISSN： 0897-7194            Impact factor:   2.511


  25 in total

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Authors:  Yuefeng Yang; Weidong Xu; Di Peng; Hao Wang; Xiaoyan Zhang; Hua Wang; Fengjun Xiao; Yitan Zhu; Yuan Ji; Kamalakar Gulukota; Donald L Helseth; Kathy A Mangold; Megan Sullivan; Karen Kaul; Edward Wang; Bellur S Prabhakar; Jinnan Li; Xuejie Wu; Lisheng Wang; Prem Seth
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Review 3.  The role of macrophage phenotype in regulating the response to radiation therapy.

Authors:  Xiaoshan Shi; Stephen L Shiao
Journal:  Transl Res       Date:  2017-11-20       Impact factor: 7.012

Review 4.  Obesity altered T cell metabolism and the response to infection.

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Journal:  Curr Opin Immunol       Date:  2017-03-27       Impact factor: 7.486

Review 5.  Emerging nanotechnologies for cancer immunotherapy.

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Journal:  Exp Biol Med (Maywood)       Date:  2016-05-04

6.  Leukocyte Gene Expression and Plasma Concentration in Multiple Sclerosis: Alteration of Transforming Growth Factor-βs, Claudin-11, and Matrix Metalloproteinase-2.

Authors:  Gholamreza Hassanzadeh; Samaneh Hosseini Quchani; Mohammad Ali Sahraian; Farid Abolhassani; Mohammad Ali Sadighi Gilani; Masoomeh Dehghan Tarzjani; Fatemeh Atoof
Journal:  Cell Mol Neurobiol       Date:  2016-01-14       Impact factor: 5.046

7.  T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38.

Authors:  Hongxing Wang; Kehua Fang; Weining Yan; Xiaotian Chang
Journal:  J Innate Immun       Date:  2021-08-24       Impact factor: 7.111

8.  Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors.

Authors:  Anupreet Kharbanda; Lingtian Zhang; Debasmita Saha; Phuc Tran; Ke Xu; Ming O Li; Yuet-Kin Leung; Brendan Frett; Hong-Yu Li
Journal:  Eur J Med Chem       Date:  2021-06-19       Impact factor: 7.088

9.  MicroRNA-490-3p inhibits colorectal cancer metastasis by targeting TGFβR1.

Authors:  Xuehu Xu; Rong Chen; Zhifa Li; Nanqi Huang; Xiaobing Wu; Shuling Li; Yong Li; Shangbiao Wu
Journal:  BMC Cancer       Date:  2015-12-29       Impact factor: 4.430

10.  Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence.

Authors:  Ping Niu; Aibek Smagul; Lu Wang; Aiman Sadvakas; Ying Sha; Laura M Pérez; Aliya Nussupbekova; Aday Amirbekov; Akan A Akanov; Beatriz G Gálvez; I King Jordan; Victoria V Lunyak
Journal:  Oncotarget       Date:  2015-07-20
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