Literature DB >> 25714498

Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey.

Robert Li-Yuan Bao1, Rong Zhao, Lei Shi.   

Abstract

Over the past decade, the effectiveness of i-PrMgCl·LiCl has been constantly highlighted by a number of research groups. Its enhanced nucleophilicity brings prosperity to highly functionalized Grignard reagents, other useful bimetallic (alkali-metal) agents and nucleophilic alkylation products under mild reaction conditions. In this feature article, a comprehensive, systematical and in-depth overview of i-PrMgCl·LiCl is provided in a multidisciplinary idea. It involves the structural and kinetic perspectives of i-PrMgCl·LiCl as well as its unique reactivity and selectivity, with knowledge of the former helping to rationalize trends of the later.

Entities:  

Year:  2015        PMID： 25714498     DOI： 10.1039/c4cc10194d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

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