| Literature DB >> 25714116 |
Lingmin Wu1, Chen Xie1, Haibo Mei1, Yanling Dai1, Jianlin Han1, Vadim A Soloshonok2,3, Yi Pan1.
Abstract
Herein is reported a study of asymmetric decarboxylative Mannich addition reactions between (Ss)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine and Schiff bases derived from various aldehydes and lithium 2,2-diphenylglycinate. These reactions proceed with excellent diastereoselectivities and good chemical yields, providing a practical method for preparation of trifluoromethyl-containing vicinal diamines. The procedures can be conducted under convenient conditions, rendering this approach of high synthetic value.Entities:
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Year: 2015 PMID： 25714116 DOI： 10.1021/acs.joc.5b00124
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354