Literature DB >> 25713730

The role of transcription factors in atrial fibrillation.

Mengchen Zhou1, Yuhua Liao1, Xin Tu1.   

Abstract

Atrial fibrillation (AF) is a complex disease that results from genetic and environmental factors and their interactions. In recent years, genome-wide association studies (GWAS) and family-based linkage analysis have found amounts of genetic variants associated with AF. Some of them lie in coding sequences and thus mediate the encoded proteins, some in non-coding regions and influence the expression of adjacent genes. These variants exert influence on the development of cardiovascular system and normal cardiac electrical activity in different levels, and eventually contribute to the occurrence of AF. Among these affected genes, as a crucial means of transcriptional regulation, several transcription factors play important roles in the pathogenesis of AF. In this review, we will focus on the potential role of PITX2, PRRX1, ZHFX3, TBX5, and NKX2.5 in AF.

Entities:  

Keywords:  Atrial fibrillation (AF); NKX2.5; PITX2; PRRX1; TBX5; ZFHX3; transcription factors

Year:  2015        PMID： 25713730      PMCID： PMC4321073          DOI： 10.3978/j.issn.2072-1439.2015.01.21

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN： 2072-1439            Impact factor:   2.895


  88 in total

1.  Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

Authors:  Babar Parvez; Joseph Vaglio; Shane Rowan; Raafia Muhammad; Gayle Kucera; Tanya Stubblefield; Shannon Carter; Dan Roden; Dawood Darbar
Journal:  J Am Coll Cardiol       Date:  2012-06-20       Impact factor: 24.094

2.  Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox.

Authors:  M B Hautmann; M M Thompson; E A Swartz; E N Olson; G K Owens
Journal:  Circ Res       Date:  1997-10       Impact factor: 17.367

3.  Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium.

Authors:  Mathilda T M Mommersteeg; Nigel A Brown; Owen W J Prall; Corrie de Gier-de Vries; Richard P Harvey; Antoon F M Moorman; Vincent M Christoffels
Journal:  Circ Res       Date:  2007-09-06       Impact factor: 17.367

4.  Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes.

Authors:  Ye Tao; Min Zhang; Lele Li; Yan Bai; Yuefang Zhou; Anne M Moon; Henry J Kaminski; James F Martin
Journal:  Circ Cardiovasc Genet       Date:  2014-01-06

5.  Patterns of paired-related homeobox genes PRX1 and PRX2 suggest involvement in matrix modulation in the developing chick vascular system.

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Journal:  Dev Dyn       Date:  1998-09       Impact factor: 3.780

6.  Loss of function of the Prx1 and Prx2 homeobox genes alters architecture of the great elastic arteries and ductus arteriosus.

Authors:  M Bergwerff; A C Gittenberger-de Groot; L J Wisse; M C DeRuiter; A Wessels; J F Martin; E N Olson; M J Kern
Journal:  Virchows Arch       Date:  2000-01       Impact factor: 4.064

7.  Pulmonary vein variants predispose to atrial fibrillation: a case-control study using multislice contrast-enhanced computed tomography.

Authors:  Alex Bittner; Gerold Mönnig; Ann Janine Vagt; Stephan Zellerhoff; Kristina Wasmer; Julia Köbe; Christian Pott; Peter Milberg; Cristina Sauerland; Johannes Wessling; Lars Eckardt
Journal:  Europace       Date:  2011-05-18       Impact factor: 5.214

8.  PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.

Authors:  Mrudula Ganga; Herbert M Espinoza; Carol J Cox; Lisa Morton; Tord A Hjalt; Youngsook Lee; Brad A Amendt
Journal:  J Biol Chem       Date:  2003-04-11       Impact factor: 5.157

Review 9.  New risk factors for atrial fibrillation: causes of 'not-so-lone atrial fibrillation'.

Authors:  Bas A Schoonderwoerd; Marcelle D Smit; Lucas Pen; Isabelle C Van Gelder
Journal:  Europace       Date:  2008-05-13       Impact factor: 5.214

10.  Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor.

Authors:  D A Grueneberg; S Natesan; C Alexandre; M Z Gilman
Journal:  Science       Date:  1992-08-21       Impact factor: 47.728
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  10 in total

Review 1.  Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.

Authors:  Alexander T Mikhailov; Mario Torrado
Journal:  Heart Fail Rev       Date:  2016-11       Impact factor: 4.214

Review 2.  Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation.

Authors:  Alexander T Mikhailov; Mario Torrado
Journal:  J Mol Med (Berl)       Date:  2018-05-12       Impact factor: 4.599

Review 3.  Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function.

Authors:  Arne A N Bruyneel; Wesley L McKeithan; Dries A M Feyen; Mark Mercola
Journal:  Curr Cardiol Rep       Date:  2018-05-25       Impact factor: 2.931

4.  Association of Single Nucleotide Polymorphisms with Atrial Fibrillation and the Outcome after Catheter Ablation.

Authors:  Yu-Feng Hu; Hsueh-Hsiao Wang; Hung-I Yeh; Kun-Tai Lee; Yenn-Jiang Lin; Shih-Lin Chang; Li-Wei Lo; Ta-Chuan Tuan; Cheng-Hung Li; Tze-Fan Chao; Fa-Po Chung; Jo-Nan Liao; Paul Wei Hua Tang; Wei-Chung Tsai; Chuen-Wang Chiou; Shih-Ann Chen
Journal:  Acta Cardiol Sin       Date:  2016-09       Impact factor: 2.672

5.  Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.

Authors:  Iiro Taneli Helenius; Ryan J Haake; Yong-Jae Kwon; Jennifer A Hu; Thomas Krupinski; S Marina Casalino-Matsuda; Peter H S Sporn; Jacob I Sznajder; Greg J Beitel
Journal:  J Immunol       Date:  2015-12-07       Impact factor: 5.422

6.  Association of T66A polymorphism in CASQ2 with PR interval in a Chinese population.

Authors:  Xin Li; Li-Zhu Guo; Nian Liu; Xin Du; Rong Bai; Jian-Zeng Dong; Chang-Sheng Ma
Journal:  Herz       Date:  2020-04-14       Impact factor: 1.443

7.  ADMIRE: analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay.

Authors:  Jens Preussner; Julia Bayer; Carsten Kuenne; Mario Looso
Journal:  Epigenetics Chromatin       Date:  2015-12-01       Impact factor: 4.954

8.  Genetically Predicted Atrial Fibrillation and Valvular Heart Disease: A Two-Sample Mendelian Randomization Study.

Authors:  Jie Gao; Yulin Bai; Hongwen Ji
Journal:  Front Cardiovasc Med       Date:  2022-03-28

9.  Ionic and cellular mechanisms underlying TBX5/PITX2 insufficiency-induced atrial fibrillation: Insights from mathematical models of human atrial cells.

Authors:  Jieyun Bai; Patrick A Gladding; Martin K Stiles; Vadim V Fedorov; Jichao Zhao
Journal:  Sci Rep       Date:  2018-10-23       Impact factor: 4.379

10.  The application of novel segmentation software to create left atrial geometry for atrial fibrillation ablation: The implication of spatial resolution.

Authors:  Chye-Gen Chin; Fa-Po Chung; Yenn-Jiang Lin; Shih-Lin Chang; Li-Wei Lo; Yu-Feng Hu; Ta-Chuan Tuan; Tze-Fan Chao; Jo-Nan Liao; Chin-Yu Lin; Ting-Yung Chang; Cheng-I Wu; Chih-Min Liu; Jennifer Jeanne B Vicera; Chun-Chao Chen; Chieh-Mao Chuang; Yi-Jen Chen; Ming-Hsiung Hsieh; Shih-Ann Chen
Journal:  J Chin Med Assoc       Date:  2020-09       Impact factor: 3.396
  10 in total

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