Literature DB >> 25713083

Radicals in Berkeley?

Stuart Linn1.   

Abstract

In a previous autobiographical sketch for DNA Repair (Linn, S. (2012) Life in the serendipitous lane: excitement and gratification in studying DNA repair. DNA Repair 11, 595-605), I wrote about my involvement in research on mechanisms of DNA repair. In this Reflections, I look back at how I became interested in free radical chemistry and biology and outline some of our bizarre (at the time) observations. Of course, these studies could never have succeeded without the exceptional aid of my mentors: my teachers; the undergraduate and graduate students, postdoctoral fellows, and senior lab visitors in my laboratory; and my faculty and staff colleagues here at Berkeley. I am so indebted to each and every one of these individuals for their efforts to overcome my ignorance and set me on the straight and narrow path to success in research. I regret that I cannot mention and thank each of these mentors individually.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Keywords:  DNA Damage; DNA Repair; Hydrogen Peroxide; Nicotinamide Adenine Dinucleotide (NADH); Reactive Oxygen Species (ROS)

Mesh:

Year:  2015        PMID: 25713083      PMCID: PMC4423665          DOI: 10.1074/jbc.X115.644989

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  23 in total

1.  DNA modification mechanisms and gene activity during development.

Authors:  R Holliday; J E Pugh
Journal:  Science       Date:  1975-01-24       Impact factor: 47.728

2.  Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

Authors:  S Linn; M Kairis; R Holliday
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

3.  The mechanism of degradation of duplex deoxyribonucleic acid by the recBC enzyme of Escherichia coli K-12.

Authors:  V MacKay; S Linn
Journal:  J Biol Chem       Date:  1974-07-10       Impact factor: 5.157

4.  The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. I. Purification, subunit structure, and catalytic properties of the modification methylase.

Authors:  J A Lautenberger; S Linn
Journal:  J Biol Chem       Date:  1972-10-10       Impact factor: 5.157

5.  The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. II. Purification, subunit structure, and catalytic properties of the restriction endonuclease.

Authors:  B Eskin; S Linn
Journal:  J Biol Chem       Date:  1972-10-10       Impact factor: 5.157

6.  The recBC deoxyribonuclease of Escherichia coli K-12. Substrate specificity and reaction intermediates.

Authors:  A E Karu; V MacKay; P J Goldmark; S Linn
Journal:  J Biol Chem       Date:  1973-07-25       Impact factor: 5.157

7.  Studies of DNA polymerases alpha and beta from cultured human cells in various replicative states.

Authors:  S W Krauss; S Linn
Journal:  J Cell Physiol       Date:  1986-01       Impact factor: 6.384

8.  Localization of Fe(2+) at an RTGR sequence within a DNA duplex explains preferential cleavage by Fe(2+) and H2O2.

Authors:  P Rai; T D Cole; D E Wemmer; S Linn
Journal:  J Mol Biol       Date:  2001-10-05       Impact factor: 5.469

9.  Effects of hydrogen peroxide upon nicotinamide nucleotide metabolism in Escherichia coli: changes in enzyme levels and nicotinamide nucleotide pools and studies of the oxidation of NAD(P)H by Fe(III).

Authors:  Julia L Brumaghim; Ying Li; Ernst Henle; Stuart Linn
Journal:  J Biol Chem       Date:  2003-08-11       Impact factor: 5.157

10.  Inducible repair of oxidative DNA damage in Escherichia coli.

Authors:  B Demple; J Halbrook
Journal:  Nature       Date:  1983 Aug 4-10       Impact factor: 49.962

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