Norio Fukumori1, Yosuke Yamamoto2, Misa Takegami3, Shin Yamazaki4, Yoshihiro Onishi5, Miho Sekiguchi6, Koji Otani6, Shin-ichi Konno6, Shin-ichi Kikuchi6, Shun-ichi Fukuhara7. 1. Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Yoshida konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan Community Medical Support Institute, Faculty of Medicine, Saga University, Saga, Japan. 2. Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Yoshida konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan. 3. Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center, Suita, Japan. 4. Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Yoshida konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. 5. Institute for Health Outcomes and Process Evaluation Research (IHope International), Kyoto, Japan. 6. Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan. 7. Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Yoshida konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan Center for Innovation in Clinical Research, Fukushima Medical University, Fukushima, Japan.
Abstract
BACKGROUND: no study has examined the longitudinal association between hand-grip strength and mental health, such as depressive symptoms. OBJECTIVE: we investigated the relationship between baseline hand-grip strength and the risk of depressive symptoms. DESIGN: a prospective cohort study. SETTING AND SUBJECTS: a prospective cohort study with a 1-year follow-up was conducted using 4,314 subjects from community-dwelling individuals aged 40-79 years in two Japanese municipalities, based on the Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS, 2008-10). METHODS: we assessed baseline hand-grip strength standardised using national representative data classified by age and gender, and depressive symptoms at baseline and after the follow-up using the five-item version of the Mental Health Inventory (MHI-5). RESULTS: the 4,314 subjects had a mean age of 66.3 years, 58.5% were women, and mean unadjusted hand-grip strength was 29.8 kg. Multivariable random-effect logistic regression analysis revealed that subjects with lower hand-grip strength (per 1SD decrease) had higher odds of having depressive symptoms at baseline [adjusted odds ratio (AOR) 1.15, 95% confidence interval (CI) 1.06-1.24; P = 0.001]. Further, lower hand-grip strength (per 1SD decrease) was associated with the longitudinal development of depressive symptoms after 1 year (AOR 1.13, 95% CI 1.01-1.27; P = 0.036). CONCLUSIONS: using a large population-based sample, our results suggest that lower hand-grip strength, standardised using age and gender, is both cross-sectionally and longitudinally associated with depressive symptoms.
BACKGROUND: no study has examined the longitudinal association between hand-grip strength and mental health, such as depressive symptoms. OBJECTIVE: we investigated the relationship between baseline hand-grip strength and the risk of depressive symptoms. DESIGN: a prospective cohort study. SETTING AND SUBJECTS: a prospective cohort study with a 1-year follow-up was conducted using 4,314 subjects from community-dwelling individuals aged 40-79 years in two Japanese municipalities, based on the Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS, 2008-10). METHODS: we assessed baseline hand-grip strength standardised using national representative data classified by age and gender, and depressive symptoms at baseline and after the follow-up using the five-item version of the Mental Health Inventory (MHI-5). RESULTS: the 4,314 subjects had a mean age of 66.3 years, 58.5% were women, and mean unadjusted hand-grip strength was 29.8 kg. Multivariable random-effect logistic regression analysis revealed that subjects with lower hand-grip strength (per 1SD decrease) had higher odds of having depressive symptoms at baseline [adjusted odds ratio (AOR) 1.15, 95% confidence interval (CI) 1.06-1.24; P = 0.001]. Further, lower hand-grip strength (per 1SD decrease) was associated with the longitudinal development of depressive symptoms after 1 year (AOR 1.13, 95% CI 1.01-1.27; P = 0.036). CONCLUSIONS: using a large population-based sample, our results suggest that lower hand-grip strength, standardised using age and gender, is both cross-sectionally and longitudinally associated with depressive symptoms.
Authors: Keith A Shaughnessy; Kyle J Hackney; Brian C Clark; William J Kraemer; Donna J Terbizan; Ryan R Bailey; Ryan McGrath Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Sean A P Clouston; Charles B Hall; Minos Kritikos; David A Bennett; Steven DeKosky; Jerri Edwards; Caleb Finch; William C Kreisl; Michelle Mielke; Elaine R Peskind; Murray Raskind; Marcus Richards; Richard P Sloan; Avron Spiro; Neil Vasdev; Robert Brackbill; Mark Farfel; Megan Horton; Sandra Lowe; Roberto G Lucchini; David Prezant; Joan Reibman; Rebecca Rosen; Kacie Seil; Rachel Zeig-Owens; Yael Deri; Erica D Diminich; Bernadette A Fausto; Sam Gandy; Mary Sano; Evelyn J Bromet; Benjamin J Luft Journal: Nat Rev Neurol Date: 2021-11-18 Impact factor: 42.937