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Literature DB >> 2571245

Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit.

Abstract

Histamine H2-receptor antagonists cimetidine and oxmetidine, H2-receptor agonist dimaprit, H1-receptor antagonist chlorpheniramine and H1-receptor agonist 2-thiazolylethylamine were tested for their effects on unstimulated pancreatic exocrine secretion in anaesthetized rabbits fitted with an acute pancreatic cannula. Intravenous administration of H1 agonist induces a dose-dependent increase in pancreatic secretion but H1 antagonist have the opposite effects. Intravenous administration of H2 antagonists induces effects similar the ones produced after H1 agonist infusion. The implications of H1 and H2 receptors on exocrine pancreatic secretion are discussed.

Entities: Chemical Disease Gene Species

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Year: 1989 PMID： 2571245 DOI： 10.1007/BF02022981

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

24 in total

1. [Variations in the enzyme content of the rat pancreas as a function of the composition of the diet].

Authors: J P REBOUD; A BEN ABDEL JLIL; P DESNUELLE
Journal: Biochim Biophys Acta Date: 1962-04-09

2. A study of the pancreatic response to histamine in dogs with total gastrectomies.

Authors: H I TANKEL; L J LESTER; A RICHMAN; F HOLLANDER
Journal: Gastroenterology Date: 1957-04 Impact factor: 22.682

3. A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals.

Authors: W Lorenz; E Matejka; A Schmal; W Seidel; H J Reimann; R Uhlig; G Mann
Journal: Comp Gen Pharmacol Date: 1973-09

Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit.

1. [Variations in the enzyme content of the rat pancreas as a function of the composition of the diet].

2. A study of the pancreatic response to histamine in dogs with total gastrectomies.

3. A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals.

4. Definition and antagonism of histamine H 2 -receptors.

5. Cardiovascular studies with SK&F 93319, an antagonist of histamine at both H1- and H2-receptors.

6. Effect of cimetidine on pancreatic exocrine secretion.

7. Effect of histamine-H2-receptor antagonists on the exocrine pancreatic secretion.

8. Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ.

9. The effect of ranitidine on exocrine pancreatic secretion in the rat.

10. Histamine stimulation of digestive enzyme secretion by in vitro rabbit pancreas.

1. Cimetidine increases the pancreatic response to histamine.

2. Histaminergic modulation of hormonal control in the exocrine guinea-pig pancreas.