Literature DB >> 25712431

Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage.

Jin Zhou1, Canliang Fang, Ying Liu, Yao Zhao, Nan Zhang, Xiangjun Liu, Fuyi Wang, Dihua Shangguan.   

Abstract

A new kind of visible-light photocleavable molecule, 4-α-amino acid substituted naphthalimide, is reported. The cleavage occurred at the C-N bond between the 4-amino and the amino acid residue and released a 4-aminonaphthalimide. A lysine substituted naphthalimide exhibited a strong DNA photocleavage activity when irradiated with a blue light LED.

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Year:  2015        PMID: 25712431     DOI: 10.1039/c5ob00302d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  1 in total

1.  Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles.

Authors:  Carl-Johan Carling; Jason Olejniczak; Alexandra Foucault-Collet; Guillaume Collet; Mathieu L Viger; Viet Anh Nguyen Huu; Brendan M Duggan; Adah Almutairi
Journal:  Chem Sci       Date:  2015-12-23       Impact factor: 9.825

  1 in total

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