Literature DB >> 25712365

Decreasing pfmdr1 copy number suggests that Plasmodium falciparum in Western Cambodia is regaining in vitro susceptibility to mefloquine.

Pharath Lim1, Dalin Dek2, Vorleak Try2, Sokunthea Sreng2, Seila Suon2, Rick M Fairhurst3.   

Abstract

Dihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) for Plasmodium falciparum malaria in Cambodia but is now failing in several western provinces. To investigate artesunate plus mefloquine (AS+MQ) as a replacement ACT, we measured the prevalence of multiple pfmdr1 copies--a molecular marker for MQ resistance--in 844 P. falciparum clinical isolates collected in 2008 to 2013. The pfmdr1 copy number is decreasing in Western Cambodia, suggesting that P. falciparum is regaining in vitro susceptibility to MQ.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25712365      PMCID： PMC4394809          DOI： 10.1128/AAC.05163-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.

Authors:  Mey Bouth Denis; Reiko Tsuyuoka; Pharath Lim; Niklas Lindegardh; Poravuth Yi; Sophoan Narann Top; Duong Socheat; Thierry Fandeur; Anna Annerberg; Eva Maria Christophel; Pascal Ringwald
Journal:  Trop Med Int Health       Date:  2006-12       Impact factor: 2.622

2.  Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia.

Authors:  Mey Bouth Denis; Reiko Tsuyuoka; Yi Poravuth; Top Sophoan Narann; Suon Seila; Chim Lim; Sandra Incardona; Pharath Lim; Rithy Sem; Duong Socheat; Eva Maria Christophel; Pascal Ringwald
Journal:  Trop Med Int Health       Date:  2006-09       Impact factor: 2.622

3.  Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum.

Authors:  Mallika Imwong; Arjen M Dondorp; Francois Nosten; Poravuth Yi; Mathirut Mungthin; Sarun Hanchana; Debashish Das; Aung Phae Phyo; Khin Maung Lwin; Sasithon Pukrittayakamee; Sue J Lee; Suwannee Saisung; Kitti Koecharoen; Chea Nguon; Nicholas P J Day; Duong Socheat; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2010-04-26       Impact factor: 5.191

4.  Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007.

Authors:  Pharath Lim; Chansuda Wongsrichanalai; Pheaktra Chim; Nimol Khim; Saorin Kim; Sophy Chy; Rithy Sem; Sina Nhem; Poravuth Yi; Socheat Duong; Denis Mey Bouth; Blaise Genton; Hans-Peter Beck; Jean Gerard Gobert; William O Rogers; Jean-Yves Coppee; Thierry Fandeur; Odile Mercereau-Puijalon; Pascal Ringwald; Jacques Le Bras; Frederic Ariey
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

5.  Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum.

Authors:  M T Duraisingh; L V von Seidlein; A Jepson; P Jones; I Sambou; M Pinder; D C Warhurst
Journal:  Parasitology       Date:  2000-07       Impact factor: 3.234

6.  Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1.

Authors:  Amy L Pickard; Chansuda Wongsrichanalai; Anne Purfield; Deborah Kamwendo; Kathryn Emery; Christy Zalewski; Fumihiko Kawamoto; R Scott Miller; Steven R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

7.  Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border.

Authors:  Alisa P Alker; Pharath Lim; Rithy Sem; Naman K Shah; Poravuth Yi; Denis Mey Bouth; Reiko Tsuyuoka; Jason D Maguire; Thierry Fandeur; Frederic Ariey; Chansuda Wongsrichanalai; Steven R Meshnick
Journal:  Am J Trop Med Hyg       Date:  2007-04       Impact factor: 2.345

8.  Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia.

Authors:  Pharath Lim; Alisa P Alker; Nimol Khim; Naman K Shah; Sandra Incardona; Socheat Doung; Poravuth Yi; Denis Mey Bouth; Christiane Bouchier; Odile Mercereau Puijalon; Steven R Meshnick; Chansuda Wongsrichanalai; Thierry Fandeur; Jacques Le Bras; Pascal Ringwald; Frédéric Ariey
Journal:  Malar J       Date:  2009-01-12       Impact factor: 2.979

9.  Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum.

Authors:  D A Barnes; S J Foote; D Galatis; D J Kemp; A F Cowman
Journal:  EMBO J       Date:  1992-08       Impact factor: 11.598

10.  Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.

Authors:  William O Rogers; Rithy Sem; Thong Tero; Pheaktra Chim; Pharath Lim; Sinuon Muth; Duong Socheat; Frédéric Ariey; Chansuda Wongsrichanalai
Journal:  Malar J       Date:  2009-01-12       Impact factor: 2.979
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  20 in total

Review 1.  Understanding artemisinin-resistant malaria: what a difference a year makes.

Authors:  Rick M Fairhurst
Journal:  Curr Opin Infect Dis       Date:  2015-10       Impact factor: 4.915

Review 2.  Antimalarial Drug Resistance: A Threat to Malaria Elimination.

Authors:  Didier Menard; Arjen Dondorp
Journal:  Cold Spring Harb Perspect Med       Date:  2017-07-05       Impact factor: 6.915

3.  Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum.

Authors:  Rodrigo G Ducati; Hilda A Namanja-Magliano; Rajesh K Harijan; J Eduardo Fajardo; Andras Fiser; Johanna P Daily; Vern L Schramm
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-12       Impact factor: 11.205

Review 4.  Artemisinin-Resistant Plasmodium falciparum Malaria.

Authors:  Rick M Fairhurst; Arjen M Dondorp
Journal:  Microbiol Spectr       Date:  2016-06

5.  Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.

Authors:  Stéphane Pelleau; Eli L Moss; Satish K Dhingra; Béatrice Volney; Jessica Casteras; Stanislaw J Gabryszewski; Sarah K Volkman; Dyann F Wirth; Eric Legrand; David A Fidock; Daniel E Neafsey; Lise Musset
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-10       Impact factor: 11.205

6.  Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment.

Authors:  Rithea Leang; Walter R J Taylor; Denis Mey Bouth; Lijiang Song; Joel Tarning; Meng Chuor Char; Saorin Kim; Benoit Witkowski; Valentine Duru; Anais Domergue; Nimol Khim; Pascal Ringwald; Didier Menard
Journal:  Antimicrob Agents Chemother       Date:  2015-05-26       Impact factor: 5.191

7.  Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations.

Authors:  Valentine Duru; Nimol Khim; Rithea Leang; Saorin Kim; Anais Domergue; Nimol Kloeung; Sopheakvatey Ke; Sophy Chy; Rotha Eam; Chanra Khean; Kaknika Loch; Malen Ken; Dysoley Lek; Johann Beghain; Frédéric Ariey; Philippe J Guerin; Rekol Huy; Odile Mercereau-Puijalon; Benoit Witkowski; Didier Menard
Journal:  BMC Med       Date:  2015-12-22       Impact factor: 8.775

8.  Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Authors:  Wilson Wong; Xiao-Chen Bai; Brad E Sleebs; Tony Triglia; Alan Brown; Jennifer K Thompson; Katherine E Jackson; Eric Hanssen; Danushka S Marapana; Israel S Fernandez; Stuart A Ralph; Alan F Cowman; Sjors H W Scheres; Jake Baum
Journal:  Nat Microbiol       Date:  2017-03-13       Impact factor: 17.745

9.  High Antimalarial Efficacy of Dihydroartemisinin-Piperaquine on the China-Myanmar Border: The Calm Before the Storm.

Authors:  Rick M Fairhurst
Journal:  Am J Trop Med Hyg       Date:  2015-08-17       Impact factor: 2.345

10.  An outbreak of artemisinin resistant falciparum malaria in Eastern Thailand.

Authors:  Mallika Imwong; Thantip Jindakhad; Chanon Kunasol; Kreepol Sutawong; Phisitt Vejakama; Arjen M Dondorp
Journal:  Sci Rep       Date:  2015-11-30       Impact factor: 4.379
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