Literature DB >> 25712359

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.

Andrea Trochine1, Darren J Creek2, Paula Faral-Tello3, Michael P Barrett2, Carlos Robello4.   

Abstract

Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25712359      PMCID： PMC4394807          DOI： 10.1128/AAC.05046-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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