Literature DB >> 25711294

Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams--conversion of ikarugamycin to butremycin.

Christian Greunke1, Janine Antosch, Tobias A M Gulder.   

Abstract

Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25711294     DOI： 10.1039/c5cc00843c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Elucidation of Spirodactylone, a Polycyclic Alkaloid from the Sponge Dactylia sp., and Nonenzymatic Generation from the Co-metabolite Denigrin B.

Authors:  Unwoo Kang; Donald R Caldwell; Laura K Cartner; Dongdong Wang; Chang-Kwon Kim; Xiangrong Tian; Heidi R Bokesch; Curtis J Henrich; Girma M Woldemichael; Martin J Schnermann; Kirk R Gustafson
Journal:  Org Lett       Date:  2019-05-31       Impact factor: 6.005

Review 2.  Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.

Authors:  Franziska Hemmerling; Frank Hahn
Journal:  Beilstein J Org Chem       Date:  2016-07-20       Impact factor: 2.883

3.  Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams.

Authors:  Subhasish Saha; Wenjun Zhang; Guangtao Zhang; Yiguang Zhu; Yuchan Chen; Wei Liu; Chengshan Yuan; Qingbo Zhang; Haibo Zhang; Liping Zhang; Weimin Zhang; Changsheng Zhang
Journal:  Chem Sci       Date:  2016-10-28       Impact factor: 9.825

4.  Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase.

Authors:  He-Lin Yu; Shu-Heng Jiang; Xu-Liang Bu; Jia-Hua Wang; Jing-Yi Weng; Xiao-Mei Yang; Kun-Yan He; Zhi-Gang Zhang; Ping Ao; Jun Xu; Min-Juan Xu
Journal:  Sci Rep       Date:  2017-01-18       Impact factor: 4.379

5.  Genome Mining and Metabolic Profiling Uncover Polycyclic Tetramate Macrolactams from Streptomyces koyangensis SCSIO 5802.

Authors:  Wenjuan Ding; Jiajia Tu; Huaran Zhang; Xiaoyi Wei; Jianhua Ju; Qinglian Li
Journal:  Mar Drugs       Date:  2021-07-31       Impact factor: 5.118

6.  Outer Membrane Vesicle-Mediated Codelivery of the Antifungal HSAF Metabolites and Lytic Polysaccharide Monooxygenase in the Predatory Lysobacter enzymogenes.

Authors:  Huan Yue; Jiasong Jiang; Anna J Taylor; Aline De Lima Leite; Eric D Dodds; Liangcheng Du
Journal:  ACS Chem Biol       Date:  2021-05-25       Impact factor: 4.634
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.