Literature DB >> 2571096

Lack of effect of chronic desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat.

L Reyneke1, R Allin, V A Russell, J J Taljaard.   

Abstract

The binding of [3H]SCH 23390 to dopamine (DA) D1-receptors was measured in the nucleus accumbens of rats treated chronically with desipramine for 14 days. DA D1- and D2-receptor binding using [3H]SCH 23390 and [3H]spiperone, respectively as ligands, was determined in rats treated for 28 days. Neither Bmax nor Kd values were influenced by chronic desipramine treatment. In addition, chronic desipramine treatment (28 days) did not influence the dose dependent, quinpirole (10-1000 nM)-mediated inhibition of the electrically stimulated release of [3H]DA release and [14C]ACh from nucleus accumbens slices or the dose dependent increase in [3H]DA release and decrease in [14C]ACh release in the presence of 1 and 10 microM nomifensine. Therefore, our results suggest that the effect of chronic antidepressant treatment cannot be attributed to changes in either DA D1- or D2-receptor binding or DA D2-receptor function in the nucleus accumbens.

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Year:  1989        PMID： 2571096     DOI： 10.1007/BF00964876

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  28 in total

Review 1.  Multiple receptors for dopamine.

Authors:  J W Kebabian; D B Calne
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

2.  Stimulation of dopamine D-2 but not D-1 receptors reduces immobility time of rats in the forced swimming test: implication for antidepressant activity.

Authors:  F Borsini; A Lecci; A Mancinelli; V D'Aranno; A Meli
Journal:  Eur J Pharmacol       Date:  1988-04-13       Impact factor: 4.432

3.  Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nomifensine and benztropine.

Authors:  W H Church; J B Justice; L D Byrd
Journal:  Eur J Pharmacol       Date:  1987-07-23       Impact factor: 4.432

4.  Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test.

Authors:  L Cervo; R Samanin
Journal:  Neuropharmacology       Date:  1987-10       Impact factor: 5.250

5.  Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulation.

Authors:  S Kurumiya; S Nakajima
Journal:  Brain Res       Date:  1988-05-10       Impact factor: 3.252

6.  Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

Authors:  S J Peroutka; S H Snyder
Journal:  Science       Date:  1980-10-03       Impact factor: 47.728

Review 7.  Two dopamine receptors: biochemistry, physiology and pharmacology.

Authors:  J C Stoof; J W Kebabian
Journal:  Life Sci       Date:  1984-12-03       Impact factor: 5.037

8.  Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.

Authors:  W Billard; V Ruperto; G Crosby; L C Iorio; A Barnett
Journal:  Life Sci       Date:  1984-10-29       Impact factor: 5.037

Review 9.  Effects of chronic antidepressant treatment on pre- and post-synaptic dopaminergic mechanisms. A short review of the literature and some complementary experiments.

Authors:  P C Waldmeier
Journal:  Pol J Pharmacol Pharm       Date:  1984 Mar-Jun

10.  The modulatory effect of neurotensin on [3H]dopamine release from rat nucleus accumbens slices is enhanced after chronic desipramine treatment.

Authors:  L Reyneke; V A Russell; J J Taljaard
Journal:  Brain Res       Date:  1987-11-03       Impact factor: 3.252
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  5 in total

1.  Lack of interaction between alpha 2-adrenoceptors and dopamine D2-receptors in mediating their inhibitory effects on [3H]dopamine release from rat nucleus accumbens slices.

Authors:  V A Russell; M C Lamm; J J Taljaard
Journal:  Neurochem Res       Date:  1993-03       Impact factor: 3.996

2.  Increased dopamine D2 receptor-mediated inhibition of [14C]acetylcholine release in the dorsomedial part of the nucleus accumbens.

Authors:  V A Russell; R Allin; M C Lamm; J J Taljaard
Journal:  Neurochem Res       Date:  1989-09       Impact factor: 3.996

3.  Effect of amygdaloid kindling on rat striatal dopamine D1- and D2-receptors.

Authors:  R Allin; M Mintz; V Russell; A Engelbrecht; M Lamm; W Daniels; G van der Spuy; A Jaffer; L Kellaway; J Taljaard
Journal:  Neurochem Res       Date:  1994-07       Impact factor: 3.996

4.  Regional distribution of monoamines and dopamine D1- and D2-receptors in the striatum of the rat.

Authors:  V A Russell; R Allin; M C Lamm; J J Taljaard
Journal:  Neurochem Res       Date:  1992-04       Impact factor: 3.996

5.  Regional effects of neurotensin on the electrically stimulated release of [3H]dopamine and [14C]acetylcholine in the rat nucleus accumbens.

Authors:  L Reyneke; V A Russell; J J Taljaard
Journal:  Neurochem Res       Date:  1992-11       Impact factor: 3.996
  5 in total

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