[Evaluation of the action of ivermectin on blood-sucking mosquitoes].

The effect of Ivomec, a formulation of ivermectin administered by various routes: through biological membrane and feeder animal was assessed. Higher insecticidal effect was obtained by feeding mosquitoes with blood containing ivermectin through biological membrane. Anopheles stephensi females were the most sensitive of 3 species under study. Their total death after feeding was observed at 1 ppm, while for Aedes aegypti the lethal dose was 2.5 ppm and for An. sacharovi, 50 ppm. Subcutaneous injection of the drug to rabbits at the dose 0.34 mg/kg wt with further feeding on it of 3 Anopheles species demonstrated the highest drug sensitivity of An. stephensi mosquitoes. Death rates among the females fed on the rabbit 4-6 days after injection of the drug were 93, 70 and 79%, respectively. Death rates among An. sacharovi and An. atroparvus differed only slightly from that of the control group. In some experiments ivermectin effect on female fertility and larvae hatching from ova can be traced. Probably, increasing the preparation dose, administered to an animal-feeder, may change significantly characteristics of the malaria carrier natural population. Moreover, further use of ivermectin versus helminths and mosquitoes in zootechnical practice may produce a side-effect on mosquitoes, feeding recurrently on domestic animals, thus increasing the effect of malaria zoological control.