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Literature DB >> 2571021

Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome.

L Gallimberti¹, G Canton, N Gentile, M Ferri, M Cibin, S D Ferrara, F Fadda, G L Gessa.

Abstract

The effect of gamma-hydroxybutyric acid (GHB) on ethanol withdrawal syndrome in alcoholics was investigated in a randomised double-blind study. Patients with withdrawal symptoms were treated either with GHB (orally in a syrup preparation) (11 patients) or with the syrup alone (12). GHB treatment (50 mg/kg) led to a prompt reduction in withdrawal symptoms, such as tremors, sweating, nausea, depression, anxiety, and restlessness. The only side-effect was dizziness. GHB may be useful in the management of alcohol withdrawal syndrome in man.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2571021 DOI： 10.1016/s0140-6736(89)90842-8

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

27 in total

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2. Advances in understanding alcohol withdrawal states.

Authors: F J Lichtigfeld; M A Gillman
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Review 3. Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users.

Authors: D I Quinn; A Wodak; R O Day
Journal: Clin Pharmacokinet Date: 1997-11 Impact factor: 6.447

Review 4. Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome.

Authors: Laura Amato; Silvia Minozzi; Marina Davoli
Journal: Cochrane Database Syst Rev Date: 2011-06-15

5. Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal.

Authors: Enrico Sanna; Maria Cristina Mostallino; Fabio Busonero; Giuseppe Talani; Stefania Tranquilli; Manuel Mameli; Saturnino Spiga; Paolo Follesa; Giovanni Biggio
Journal: J Neurosci Date: 2003-12-17 Impact factor: 6.167

Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome.

Review 1. Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function.

2. Advances in understanding alcohol withdrawal states.

Review 3. Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users.

Review 4. Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome.

5. Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal.

6. Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers.

7. Clinical efficacy of gamma-hydroxybutyric acid in treatment of opiate withdrawal.

8. Forensic toxicology findings in deaths involving gamma-hydroxybutyrate.

9. Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses.

Review 10. Gamma hydroxybutyric acid (GHB) for the treatment of alcohol dependence: a review.