Literature DB >> 2570843

Rapid production of ulcerative disease of the colon in newly-weaned guinea-pigs by degraded carrageenan.

A J Marcus1, S N Marcus, R Marcus, J Watt.   

Abstract

In a dose-response study, degraded carrageenan (Eucheuma spinosum) was supplied in the drinking fluid at 1.2 and 3% concentrations over two weeks to young adult guinea-pigs. Ulceration of the large bowel was produced in 100% of animals, the severity and extent of damage probably being dose-related. In a time-course study, 3% degraded carrageenan solution supplied to newly-weaned guinea-pigs produced in 100% of animals ulceration in the caecum by four days and in the ascending colon by seven days. The onset of ulceration occurred as early as the second day. This model is convenient and economic for the screening of drugs of potential therapeutic value in human ulcerative colitis.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2570843     DOI： 10.1111/j.2042-7158.1989.tb06493.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  9 in total

1.  Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats.

Authors:  J K Furne; F L Suarez; S L Ewing; J Springfield; M D Levitt
Journal:  Dig Dis Sci       Date:  2000-07       Impact factor: 3.199

2.  The pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea-pig.

Authors:  S N Marcus; A J Marcus; R Marcus; S W Ewen; J Watt
Journal:  Int J Exp Pathol       Date:  1992-08       Impact factor: 1.925

3.  Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes.

Authors:  Jan-Hendrik Hehemann; Amelia G Kelly; Nicholas A Pudlo; Eric C Martens; Alisdair B Boraston
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-12       Impact factor: 11.205

Review 4.  Review of harmful gastrointestinal effects of carrageenan in animal experiments.

Authors:  J K Tobacman
Journal:  Environ Health Perspect       Date:  2001-10       Impact factor: 9.031

Review 5.  Spontaneous and Induced Tumors in Germ-Free Animals: A General Review.

Authors:  Rajbardhan Mishra; Lenka Rajsiglová; Pavol Lukáč; Paolo Tenti; Peter Šima; Fabián Čaja; Luca Vannucci
Journal:  Medicina (Kaunas)       Date:  2021-03-11       Impact factor: 2.430

6.  Degraded carrageenan causing colitis in rats induces TNF secretion and ICAM-1 upregulation in monocytes through NF-kappaB activation.

Authors:  Claudine Benard; Antonietta Cultrone; Catherine Michel; Carlos Rosales; Jean-Pierre Segain; Marc Lahaye; Jean-Paul Galmiche; Christine Cherbut; Hervé M Blottière
Journal:  PLoS One       Date:  2010-01-13       Impact factor: 3.240

7.  Mechanisms of motility change on trinitrobenzenesulfonic Acid-induced colonic inflammation in mice.

Authors:  Gab Jin Cheon; Yuan Cui; Dong-Soo Yeon; Seong-Chun Kwon; Byong-Gon Park
Journal:  Korean J Physiol Pharmacol       Date:  2012-12-10       Impact factor: 2.016

Review 8.  Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota.

Authors:  Raúl E Cian; Silvina R Drago; Fermín Sánchez de Medina; Olga Martínez-Augustin
Journal:  Mar Drugs       Date:  2015-08-20       Impact factor: 5.118

9.  Molecular basis of carrageenan-induced cytokines production in macrophages.

Authors:  Alexandre H Lopes; Rangel L Silva; Miriam D Fonseca; Francisco I Gomes; Alexandre G Maganin; Lucas S Ribeiro; Lucas Maciel Mauriz Marques; Fernando Q Cunha; Jose C Alves-Filho; Dario S Zamboni; Norberto P Lopes; Bernardo S Franklin; Aurélie Gombault; Fernando Silva Ramalho; Valerie F J Quesniaux; Isabelle Couillin; Bernhard Ryffel; Thiago M Cunha
Journal:  Cell Commun Signal       Date:  2020-09-07       Impact factor: 5.712
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.