Literature DB >> 25708428

In-situ formation of growth-factor-loaded coacervate microparticle-embedded hydrogels for directing encapsulated stem cell fate.

Oju Jeon1, David W Wolfson, Eben Alsberg.   

Abstract

The spontaneous formation of coacervate microdroplet-laden photo-crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug-laden microdroplets and encapsulation of stem cells in photopolymerized coacervate hydrogels under physiological conditions. This can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulate stem cells for therapeutic applications.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  alginate; coacervate; gelatin; microdroplet; microencapsulation

Mesh：

Substances：

Year:  2015        PMID： 25708428      PMCID： PMC4408272          DOI： 10.1002/adma.201405337

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  30 in total

Review 1.  Protein instability in poly(lactic-co-glycolic acid) microparticles.

Authors:  M van de Weert; W E Hennink; W Jiskoot
Journal:  Pharm Res       Date:  2000-10       Impact factor: 4.200

2.  Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation.

Authors:  Sungwoo Kim; Yunqing Kang; Chad A Krueger; Milan Sen; John B Holcomb; Di Chen; Joseph C Wenke; Yunzhi Yang
Journal:  Acta Biomater       Date:  2012-01-18       Impact factor: 8.947

Review 3.  Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles.

Authors:  Ugo Bilati; Eric Allémann; Eric Doelker
Journal:  Eur J Pharm Biopharm       Date:  2005-04       Impact factor: 5.571

4.  Complexation and coacervation of polyelectrolytes with oppositely charged colloids.

Authors:  Ebru Kizilay; A Basak Kayitmazer; Paul L Dubin
Journal:  Adv Colloid Interface Sci       Date:  2011-07-08       Impact factor: 12.984

5.  Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels.

Authors:  Oju Jeon; Caitlin Powell; Loran D Solorio; Melissa D Krebs; Eben Alsberg
Journal:  J Control Release       Date:  2011-07-02       Impact factor: 9.776

6.  Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis.

Authors:  Hunghao Chu; Jin Gao; Chien-Wen Chen; Johnny Huard; Yadong Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-01       Impact factor: 11.205

7.  Promotion of osteoblast proliferation on complex coacervation-based hyaluronic acid - recombinant mussel adhesive protein coatings on titanium.

Authors:  Dong Soo Hwang; J Herbert Waite; Matthew Tirrell
Journal:  Biomaterials       Date:  2009-11-04       Impact factor: 12.479

8.  Human progenitor cell recruitment via SDF-1α coacervate-laden PGS vascular grafts.

Authors:  Kee-Won Lee; Noah R Johnson; Jin Gao; Yadong Wang
Journal:  Biomaterials       Date:  2013-09-20       Impact factor: 12.479

9.  Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering.

Authors:  Pinar Yilgor; Kadriye Tuzlakoglu; Rui L Reis; Nesrin Hasirci; Vasif Hasirci
Journal:  Biomaterials       Date:  2009-04-09       Impact factor: 12.479

10.  Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications.

Authors:  Oju Jeon; Julia E Samorezov; Eben Alsberg
Journal:  Acta Biomater       Date:  2013-09-12       Impact factor: 8.947
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  28 in total

1.  Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives.

Authors:  Kan Yue; Xiuyu Li; Karsten Schrobback; Amir Sheikhi; Nasim Annabi; Jeroen Leijten; Weijia Zhang; Yu Shrike Zhang; Dietmar W Hutmacher; Travis J Klein; Ali Khademhosseini
Journal:  Biomaterials       Date:  2017-05-29       Impact factor: 12.479

2.  RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects.

Authors:  Minh K Nguyen; Oju Jeon; Phuong N Dang; Cong T Huynh; Davood Varghai; Hooman Riazi; Alexandra McMillan; Samuel Herberg; Eben Alsberg
Journal:  Acta Biomater       Date:  2018-06-07       Impact factor: 8.947

3.  Cell and Biologic-Based Treatment of Flexor Tendon Injuries.

Authors:  Stephen W Linderman; Richard H Gelberman; Stavros Thomopoulos; Hua Shen
Journal:  Oper Tech Orthop       Date:  2016-09

4.  Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues.

Authors:  Oju Jeon; Yu Bin Lee; Thomas J Hinton; Adam W Feinberg; Eben Alsberg
Journal:  Mater Today Chem       Date:  2019-01-14

5.  Tunable Hydrogels: Introduction to the World of Smart Materials for Biomedical Applications.

Authors:  Iliyana Pepelanova
Journal:  Adv Biochem Eng Biotechnol       Date:  2021       Impact factor: 2.635

Review 6.  Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications.

Authors:  Fuli Zhao; Dan Yao; Ruiwei Guo; Liandong Deng; Anjie Dong; Jianhua Zhang
Journal:  Nanomaterials (Basel)       Date:  2015-12-03       Impact factor: 5.076

7.  Hydrogel microparticles for biomedical applications.

Authors:  Andrew C Daly; Lindsay Riley; Tatiana Segura; Jason A Burdick
Journal:  Nat Rev Mater       Date:  2019-11-07       Impact factor: 66.308

8.  Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation.

Authors:  Minh Khanh Nguyen; Alexandra McMillan; Cong Truc Huynh; Daniel S Schapira; Eben Alsberg
Journal:  J Mater Chem B       Date:  2016-12-14       Impact factor: 6.331

9.  Ultrastrong and Flexible Hybrid Hydrogels based on Solution Self-Assembly of Chitin Nanofibers in Gelatin Methacryloyl (GelMA).

Authors:  P Hassanzadeh; M Kazemzadeh-Narbat; R Rosenzweig; X Zhang; A Khademhosseini; N Annabi; M Rolandi
Journal:  J Mater Chem B       Date:  2016-02-23       Impact factor: 6.331

Review 10.  Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.

Authors:  Kan Yue; Grissel Trujillo-de Santiago; Mario Moisés Alvarez; Ali Tamayol; Nasim Annabi; Ali Khademhosseini
Journal:  Biomaterials       Date:  2015-08-28       Impact factor: 12.479
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