| Literature DB >> 2570837 |
F M Williams1, E M Mutch, E Nicholson, H Wynne, P Wright, D Lambert, M D Rawlins.
Abstract
The plasma, in addition to the liver, is a major site of hydrolysis of aspirin. Human plasma and liver aspirin esterase activities in samples from a group of patients varied over a two fold range and there was a significant correlation between individual plasma and liver activities. Human liver aspirin esterase was present in the cytosolic and microsomal fractions. Cytosolic and microsomal enzymes had different activities and apparent affinities for aspirin.Entities:
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Year: 1989 PMID： 2570837 DOI： 10.1111/j.2042-7158.1989.tb06487.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765