Literature DB >> 25708309

Building a roadmap for developing combination therapies for Alzheimer's disease.

Daniel Perry1, Reisa Sperling, Russell Katz, Donald Berry, David Dilts, Debra Hanna, Stephen Salloway, John Q Trojanowski, Chas Bountra, Michael Krams, Johan Luthman, Steven Potkin, Val Gribkoff, Robert Temple, Yaning Wang, Maria C Carrillo, Diane Stephenson, Heather Snyder, Enchi Liu, Tony Ware, John McKew, F Owen Fields, Lisa J Bain, Cynthia Bens.   

Abstract

Combination therapy has proven to be an effective strategy for treating many of the world's most intractable diseases. A growing number of investigators in academia, industry, regulatory agencies, foundations and advocacy organizations are interested in pursuing a combination approach to treating Alzheimer's disease. A meeting co-hosted by the Accelerate Cure/Treatments for Alzheimer's Disease Coalition, the Critical Path Institute and the Alzheimer's Association addressed challenges in designing clinical trials to test multiple treatments in combination and outlined a roadmap for making such trials a reality.

Entities:  

Keywords:  Alzheimer’ disease; co-development; collaboration; combination therapy; novel therapy

Mesh：

Year:  2015        PMID： 25708309      PMCID： PMC4608368          DOI： 10.1586/14737175.2015.996551

Source DB:  PubMed          Journal:  Expert Rev Neurother        ISSN： 1473-7175            Impact factor:   4.618


  8 in total

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Authors:  Stanley B Prusiner
Journal:  Science       Date:  2012-06-22       Impact factor: 47.728

2.  I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy.

Authors:  A D Barker; C C Sigman; G J Kelloff; N M Hylton; D A Berry; L J Esserman
Journal:  Clin Pharmacol Ther       Date:  2009-05-13       Impact factor: 6.875

3.  Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.

Authors:  Clifford R Jack; David S Knopman; William J Jagust; Ronald C Petersen; Michael W Weiner; Paul S Aisen; Leslie M Shaw; Prashanthi Vemuri; Heather J Wiste; Stephen D Weigand; Timothy G Lesnick; Vernon S Pankratz; Michael C Donohue; John Q Trojanowski
Journal:  Lancet Neurol       Date:  2013-02       Impact factor: 44.182

4.  Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

Authors:  Bin Zhang; Chris Gaiteri; Liviu-Gabriel Bodea; Zhi Wang; Joshua McElwee; Alexei A Podtelezhnikov; Chunsheng Zhang; Tao Xie; Linh Tran; Radu Dobrin; Eugene Fluder; Bruce Clurman; Stacey Melquist; Manikandan Narayanan; Christine Suver; Hardik Shah; Milind Mahajan; Tammy Gillis; Jayalakshmi Mysore; Marcy E MacDonald; John R Lamb; David A Bennett; Cliona Molony; David J Stone; Vilmundur Gudnason; Amanda J Myers; Eric E Schadt; Harald Neumann; Jun Zhu; Valur Emilsson
Journal:  Cell       Date:  2013-04-25       Impact factor: 41.582

Review 5.  Charting a path toward combination therapy for Alzheimer's disease.

Authors:  Diane Stephenson; Dan Perry; Cynthia Bens; Lisa J Bain; Donald Berry; Michael Krams; Reisa Sperling; David Dilts; Johan Luthman; Debra Hanna; John McKew; Robert Temple; F Owen Fields; Stephen Salloway; Russell Katz
Journal:  Expert Rev Neurother       Date:  2014-12-26       Impact factor: 4.618

6.  Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade.

Authors:  Clifford R Jack; David S Knopman; William J Jagust; Leslie M Shaw; Paul S Aisen; Michael W Weiner; Ronald C Petersen; John Q Trojanowski
Journal:  Lancet Neurol       Date:  2010-01       Impact factor: 44.182

7.  Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

Authors:  Randall J Bateman; Chengjie Xiong; Tammie L S Benzinger; Anne M Fagan; Alison Goate; Nick C Fox; Daniel S Marcus; Nigel J Cairns; Xianyun Xie; Tyler M Blazey; David M Holtzman; Anna Santacruz; Virginia Buckles; Angela Oliver; Krista Moulder; Paul S Aisen; Bernardino Ghetti; William E Klunk; Eric McDade; Ralph N Martins; Colin L Masters; Richard Mayeux; John M Ringman; Martin N Rossor; Peter R Schofield; Reisa A Sperling; Stephen Salloway; John C Morris
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8.  Genome-wide association study of Alzheimer's disease.

Authors:  M I Kamboh; F Y Demirci; X Wang; R L Minster; M M Carrasquillo; V S Pankratz; S G Younkin; A J Saykin; G Jun; C Baldwin; M W Logue; J Buros; L Farrer; M A Pericak-Vance; J L Haines; R A Sweet; M Ganguli; E Feingold; S T Dekosky; O L Lopez; M M Barmada
Journal:  Transl Psychiatry       Date:  2012-05-15       Impact factor: 6.222
  8 in total
  21 in total

1.  Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease.

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Journal:  Mol Psychiatry       Date:  2016-07-19       Impact factor: 15.992

2.  Computational Analysis of Therapeutic Neuroadaptation to Chronic Antidepressant in a Model of the Monoaminergic Neurotransmitter and Stress Hormone Systems.

Authors:  Mariam B Camacho; Warut D Vijitbenjaronk; Thomas J Anastasio
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3.  The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model.

Authors:  Randall J Bateman; Tammie L Benzinger; Scott Berry; David B Clifford; Cynthia Duggan; Anne M Fagan; Kathleen Fanning; Martin R Farlow; Jason Hassenstab; Eric M McDade; Susan Mills; Katrina Paumier; Melanie Quintana; Stephen P Salloway; Anna Santacruz; Lon S Schneider; Guoqiao Wang; Chengjie Xiong
Journal:  Alzheimers Dement       Date:  2016-08-29       Impact factor: 21.566

4.  Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.

Authors:  John L Robinson; Edward B Lee; Sharon X Xie; Lior Rennert; EunRan Suh; Colin Bredenberg; Carrie Caswell; Vivianna M Van Deerlin; Ning Yan; Ahmed Yousef; Howard I Hurtig; Andrew Siderowf; Murray Grossman; Corey T McMillan; Bruce Miller; John E Duda; David J Irwin; David Wolk; Lauren Elman; Leo McCluskey; Alice Chen-Plotkin; Daniel Weintraub; Steven E Arnold; Johannes Brettschneider; Virginia M-Y Lee; John Q Trojanowski
Journal:  Brain       Date:  2018-07-01       Impact factor: 13.501

Review 5.  Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.

Authors:  Mansi R Khanna; Jane Kovalevich; Virginia M-Y Lee; John Q Trojanowski; Kurt R Brunden
Journal:  Alzheimers Dement       Date:  2016-10       Impact factor: 21.566

6.  Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment.

Authors:  David A Loewenstein; Rosie E Curiel; Steven DeKosky; Russell M Bauer; Monica Rosselli; Salvador M Guinjoan; Malek Adjouadi; Ailyn Peñate; William W Barker; Sindy Goenaga; Todd Golde; Maria T Greig-Custo; Kevin S Hanson; Chunfei Li; Gabriel Lizarraga; Michael Marsiske; Ranjan Duara
Journal:  Neurology       Date:  2018-08-03       Impact factor: 9.910

Review 7.  The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.

Authors:  Valentin K Gribkoff; Leonard K Kaczmarek
Journal:  Neuropharmacology       Date:  2016-03-12       Impact factor: 5.250

Review 8.  The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement.

Authors:  Michael W Weiner; Dallas P Veitch; Paul S Aisen; Laurel A Beckett; Nigel J Cairns; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; John C Morris; Ronald C Petersen; Jennifer Salazar; Andrew J Saykin; Leslie M Shaw; Arthur W Toga; John Q Trojanowski
Journal:  Alzheimers Dement       Date:  2016-12-05       Impact factor: 21.566

9.  Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.

Authors:  Fares Bassil; Hannah J Brown; Shankar Pattabhiraman; Joe E Iwasyk; Chantal M Maghames; Emily S Meymand; Timothy O Cox; Dawn M Riddle; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Journal:  Neuron       Date:  2019-11-20       Impact factor: 17.173

Review 10.  Mild Cognitive Impairment.

Authors:  Ronald C Petersen
Journal:  Continuum (Minneap Minn)       Date:  2016-04
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