OBJECTIVES: To study the correlation of obesity with various metabolic parameters and correlation between insulin resistance and leptin and retinol binding protein 4 (RBP4) levels. METHODS: This is a cross sectional study in a tertiary care children's hospital wherein 98 obese children were included and their metabolic parameters analysed with regards to insulin resistance and RBP4 levels. RESULTS: Leptin levels were abnormal for all children and high RBP4 levels were observed in 69.6 %. There was no significant association between insulin resistance and RBP4 levels (p 0.8). CONCLUSIONS: RBP4, the sole retinol transporter in blood, secreted from adipocytes and liver has been implicated in insulin resistance. The index study however, did not show a significant positive association.
OBJECTIVES: To study the correlation of obesity with various metabolic parameters and correlation between insulin resistance and leptin and retinol binding protein 4 (RBP4) levels. METHODS: This is a cross sectional study in a tertiary care children's hospital wherein 98 obesechildren were included and their metabolic parameters analysed with regards to insulin resistance and RBP4 levels. RESULTS: Leptin levels were abnormal for all children and high RBP4 levels were observed in 69.6 %. There was no significant association between insulin resistance and RBP4 levels (p 0.8). CONCLUSIONS:RBP4, the sole retinol transporter in blood, secreted from adipocytes and liver has been implicated in insulin resistance. The index study however, did not show a significant positive association.
Authors: Qin Yang; Timothy E Graham; Nimesh Mody; Frederic Preitner; Odile D Peroni; Janice M Zabolotny; Ko Kotani; Loredana Quadro; Barbara B Kahn Journal: Nature Date: 2005-07-21 Impact factor: 49.962
Authors: Mary Savoye; Melissa Shaw; James Dziura; William V Tamborlane; Paulina Rose; Cindy Guandalini; Rachel Goldberg-Gell; Tania S Burgert; Anna M G Cali; Ram Weiss; Sonia Caprio Journal: JAMA Date: 2007-06-27 Impact factor: 56.272
Authors: Christina Kanaka-Gantenbein; Alexandra Margeli; Panagiota Pervanidou; Sophia Sakka; George Mastorakos; George P Chrousos; Ioannis Papassotiriou Journal: Clin Chem Date: 2008-05-16 Impact factor: 8.327