Literature DB >> 2570784

Ischemic flow threshold for extracellular glutamate increase in cat cortex.

N Shimada1, R Graf, G Rosner, A Wakayama, C P George, W D Heiss.   

Abstract

Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of anesthetized cats during global ischemia of various severities. A threshold-type relationship was observed between extracellular Glu and CBF: Glu increased at CBF levels below about 20 ml/100 g/min. The Glu increase was related to the impairment of AEPs. The results suggest that Glu neurotoxicity is an important factor for ischemic neuronal injury even in penumbra.

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Year:  1989        PMID： 2570784     DOI： 10.1038/jcbfm.1989.86

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  16 in total

1.  Cortical brain microdialysis and temperature monitoring during hypothermic circulatory arrest in humans.

Authors:  A Mendelowitsch; G W Mergner; A Shuaib; L N Sekhar
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-05       Impact factor: 10.154

Review 2.  Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke.

Authors:  Savita Khanna; Zachary Briggs; Cameron Rink
Journal:  Antioxid Redox Signal       Date:  2015-01-10       Impact factor: 8.401

Review 3.  The role of glutamate in neuronal ischemic injury: the role of spark in fire.

Authors:  Botros B Kostandy
Journal:  Neurol Sci       Date:  2011-11-02       Impact factor: 3.307

4.  Distinct spatiotemporal patterns of spreading depolarizations during early infarct evolution: evidence from real-time imaging.

Authors:  Tetsuya Kumagai; Maureen Walberer; Hajime Nakamura; Heike Endepols; Michael Sué; Stefan Vollmar; Sasan Adib; Günter Mies; Toshiki Yoshimine; Michael Schroeter; Rudolf Graf
Journal:  J Cereb Blood Flow Metab       Date:  2010-08-11       Impact factor: 6.200

Review 5.  Molecular pathways in cerebral ischemia: cues to novel therapeutic strategies.

Authors:  Brigitte Onténiente; Sowmyalakshmí Rasika; Alexandra Benchoua; Christelle Guégan
Journal:  Mol Neurobiol       Date:  2003-02       Impact factor: 5.590

6.  Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage.

Authors:  Giovanni Grasso; Michele Buemi; Concetta Alafaci; Alessandra Sfacteria; Marcello Passalacqua; Alessio Sturiale; Gioacchino Calapai; Gionata De Vico; Giuseppe Piedimonte; Francesco M Salpietro; Francesco Tomasello
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

7.  Elevation of the extracellular glutamate concentration in the hippocampus after total cerebral ischemia related to the deterioration of the recovery in EEG and evoked potentials in dogs.

Authors:  K Ono; N Iwatsuki; T Tajima; M Takahashi; Y Hashimoto
Journal:  J Anesth       Date:  1993-07       Impact factor: 2.078

Review 8.  Pathophysiology of the ischemic penumbra--revision of a concept.

Authors:  T Back
Journal:  Cell Mol Neurobiol       Date:  1998-12       Impact factor: 5.046

9.  Flow threshold for enhanced phorbol ester binding in the ischemic gerbil brain.

Authors:  K Tanaka; Y Fukuuchi; S Gomi; S Takashima; B Mihara; T Shirai; S Nogawa; H Nozaki; E Nagata; T Kondo
Journal:  Neurochem Res       Date:  1995-09       Impact factor: 3.996

Review 10.  Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man.

Authors:  J McCulloch
Journal:  Br J Clin Pharmacol       Date:  1992-08       Impact factor: 4.335
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