Literature DB >> 25707543

Betamethasone augments the antifungal effect of menadione--towards a novel anti-Candida albicans combination therapy.

Ágnes Jakab1, Tamás Emri1, Lilla Sipos1, Ágnes Kiss1, Renátó Kovács2, Viktor Dombrádi3, Ádám Kemény-Beke4, József Balla5, László Majoros2, István Pócsi1.   

Abstract

The fluorinated glucocorticoid betamethasone stimulated both the extracellular phospholipase production and hypha formation of the opportunistic human pathogen Candida albicans and also decreased the efficiency of the polyene antimycotics amphotericin B and nystatin against C. albicans in a dose-dependent manner. Importantly, betamethasone increased synergistically the anti-Candida activity of the oxidative stress generating agent menadione, which may be exploited in future combination therapies to prevent or cure C. albicans infections, in the field of dermatology.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Antimycotics; Candida albicans; Glucocorticoids; Menadione; Oxidative stress

Mesh：

Substances：

Year:  2015        PMID： 25707543     DOI： 10.1002/jobm.201400903

Source DB:  PubMed          Journal:  J Basic Microbiol        ISSN： 0233-111X            Impact factor:   2.281


  5 in total

1.  Physiological and Transcriptional Responses of Candida parapsilosis to Exogenous Tyrosol.

Authors:  Ágnes Jakab; Zoltán Tóth; Fruzsina Nagy; Dániel Nemes; Ildikó Bácskay; Gábor Kardos; Tamás Emri; István Pócsi; László Majoros; Renátó Kovács
Journal:  Appl Environ Microbiol       Date:  2019-10-01       Impact factor: 4.792

Review 2.  Menadione: a platform and a target to valuable compounds synthesis.

Authors:  Acácio S de Souza; Ruan Carlos B Ribeiro; Dora C S Costa; Fernanda P Pauli; David R Pinho; Matheus G de Moraes; Fernando de C da Silva; Luana da S M Forezi; Vitor F Ferreira
Journal:  Beilstein J Org Chem       Date:  2022-04-11       Impact factor: 2.544

Review 3.  Drug repurposing strategies in the development of potential antifungal agents.

Authors:  Qian Zhang; Fangyan Liu; Meng Zeng; Yingyu Mao; Zhangyong Song
Journal:  Appl Microbiol Biotechnol       Date:  2021-06-21       Impact factor: 4.813

4.  Identification of Genomewide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses.

Authors:  Suraya Muzafar; Ravi Datta Sharma; Abdul Haseeb Shah; Naseem A Gaur; Ujjaini Dasgupta; Neeraj Chauhan; Rajendra Prasad
Journal:  mSphere       Date:  2020-08-12       Impact factor: 4.389

5.  Deletion of the fungus specific protein phosphatase Z1 exaggerates the oxidative stress response in Candida albicans.

Authors:  Krisztina Szabó; Ágnes Jakab; Szilárd Póliska; Katalin Petrényi; Katalin Kovács; Lama Hasan Bou Issa; Tamás Emri; István Pócsi; Viktor Dombrádi
Journal:  BMC Genomics       Date:  2019-11-19       Impact factor: 3.969
  5 in total

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