Mike Ripley1, Andrea Lanes2, Marie-Claude Léveillé3, Doron Shmorgun3. 1. Ottawa Fertility Centre, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: ripley.mike@gmail.com. 2. Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. 3. Ottawa Fertility Centre, University of Ottawa, Ottawa, Ontario, Canada.
Abstract
OBJECTIVE: To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles. DESIGN: Retrospective cohort study. SETTING: University-affiliated regional fertility clinic. PATIENT(S): Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013. INTERVENTION(S): Unstimulated therapeutic donor insemination. MAIN OUTCOME MEASURE(S): Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality. RESULT(S): The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36-39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count. CONCLUSION(S): AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.
OBJECTIVE: To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles. DESIGN: Retrospective cohort study. SETTING: University-affiliated regional fertility clinic. PATIENT(S): Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013. INTERVENTION(S): Unstimulated therapeutic donor insemination. MAIN OUTCOME MEASURE(S): Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality. RESULT(S): The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36-39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count. CONCLUSION(S): AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.