| Literature DB >> 25706857 |
Lei Wang1, Panpan Zhang1, Jinjin Shi1, Yongwei Hao1, Dehui Meng1, Yalin Zhao1, Yin Yanyan1, Dong Li1, Junbiao Chang1, Zhenzhong Zhang1.
Abstract
In this study, a new type of magnetic tumor-targeting PEGylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes was successfully obtained. The reverse-phase evaporation method was used to construct the magnetoliposomes, and then gold nanoshells were coated on the surface of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG2000 modification. This multifunction system was combined with a variety of functions, such as radiofrequency-triggered release, chemo-hyperthermia therapy, and dual-mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AuNSs-PEG complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosomal degradation. All results in vitro and in vivo indicated that DOX-TSMLs-AuNSs-PEG is a promising effective drug delivery system for diagnosis and treatment of tumors.Entities:
Keywords: chemo-hyperthermia therapy; controlled release; dual-mode MR/X-ray imaging; gold nanoshells; thermosensitive magnetoliposomes
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Year: 2015 PMID： 25706857 DOI： 10.1021/am507898z
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229