Literature DB >> 25705578

Melatonin, the Hormone of Darkness: From Sleep Promotion to Ebola Treatment.

Alina Masters1, Seithikurippu R Pandi-Perumal2, Azizi Seixas2, Jean-Louis Girardin2, Samy I McFarlane1.   

Abstract

Melatonin is a hormone secreted by the enigmatic pineal gland in response to darkness, hence the name hormone of darkness. It has generated a great deal of interest as a therapeutic modality for various diseases particularly sleep disorders. This pleiotropic molecule has anti-inflammatory, antioxidant and anticoagulopathic properties in addition to its endothelial protective effects. In this article we discuss melatonin secretion and mechanisms of action as well as therapeutic rationale. We also highlight the potential utility of melatonin in the deadly modern-day Ebola epidemic.

Entities:  

Keywords:  Ebola; Human; Jetlag; Melatonin; Pineal; Sleep

Year:  2014        PMID： 25705578      PMCID： PMC4334454          DOI： 10.4172/2168-975X.1000151

Source DB:  PubMed          Journal:  Brain Disord Ther        ISSN： 2168-975X


  46 in total

1.  An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia.

Authors:  Milton Erman; David Seiden; Gary Zammit; Stephen Sainati; Jeffrey Zhang
Journal:  Sleep Med       Date:  2005-11-23       Impact factor: 3.492

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3.  The role of melatonin and serotonin in aging.

Authors:  R Rozencwaig; B R Grad; J Ochoa
Journal:  Med Hypotheses       Date:  1987-08       Impact factor: 1.538

Review 4.  Functional MT1 and MT2 melatonin receptors in mammals.

Authors:  Margarita L Dubocovich; Magdalena Markowska
Journal:  Endocrine       Date:  2005-07       Impact factor: 3.633

5.  Effects of exogenous melatonin on sleep: a meta-analysis.

Authors:  Amnon Brzezinski; Mark G Vangel; Richard J Wurtman; Gillian Norrie; Irina Zhdanova; Abraham Ben-Shushan; Ian Ford
Journal:  Sleep Med Rev       Date:  2005-02       Impact factor: 11.609

Review 6.  Melatonin and human reproduction: shedding light on the darkness hormone.

Authors:  Venkatramanujam Srinivasan; Warren D Spence; Seithikurippu R Pandi-Perumal; Rahima Zakharia; Kunwar P Bhatnagar; Amnon Brzezinski
Journal:  Gynecol Endocrinol       Date:  2009-12       Impact factor: 2.260

7.  Sleep-inducing effects of exogenous melatonin administration.

Authors:  R Luboshizsky; P Lavie
Journal:  Sleep Med Rev       Date:  1998-08       Impact factor: 11.609

Review 8.  The prevalence, cost implications, and management of sleep disorders: an overview.

Authors:  Jamil L Hossain; Colin M Shapiro
Journal:  Sleep Breath       Date:  2002-06       Impact factor: 2.816

9.  Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus-Consequences to Melatonin Dysfunction.

Authors:  Rüdiger Hardeland
Journal:  Int J Mol Sci       Date:  2013-03-12       Impact factor: 5.923

Review 10.  Could agomelatine be the ideal antidepressant?

Authors:  S R Pandi-Perumal; Venkatramanujan Srinivasan; D P Cardinali; M J Monti
Journal:  Expert Rev Neurother       Date:  2006-11       Impact factor: 4.618
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  9 in total

Review 1.  Melatonin's Benefits and Risks as a Therapy for Sleep Disturbances in the Elderly: Current Insights.

Authors:  Daniel P Cardinali; Gregory M Brown; Seithikurippu R Pandi-Perumal
Journal:  Nat Sci Sleep       Date:  2022-10-14

2.  Melatonin Synergizes the Chemotherapeutic Effect of Cisplatin in Ovarian Cancer Cells Independently of MT1 Melatonin Receptors.

Authors:  Agata Zemła; Irmina Grzegorek; Piotr Dzięgiel; Karolina Jabłońska
Journal:  In Vivo       Date:  2017 Sep-Oct       Impact factor: 2.155

3.  Melatonin modulates drug-induced acute porphyria.

Authors:  Sandra M Lelli; Marta B Mazzetti; Leonor C San Martín de Viale
Journal:  Toxicol Rep       Date:  2016-01-07

4.  The Effect Of Fluvoxamine On Sleep Architecture Of Depressed Patients With Insomnia: An 8-Week, Open-Label, Baseline-Controlled Study.

Authors:  Yanli Hao; Yuanyuan Hu; Haili Wang; Dhirendra Paudel; Yan Xu; Bin Zhang
Journal:  Nat Sci Sleep       Date:  2019-11-04

Review 5.  Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features.

Authors:  Foad Rommasi; Mohammad Javad Nasiri; Mehdi Mirsaeidi
Journal:  Mol Cell Biochem       Date:  2022-01-11       Impact factor: 3.842

6.  Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields.

Authors:  E Díaz-Del Cerro; J Félix; Jaf Tresguerres; M De la Fuente
Journal:  Environ Health       Date:  2022-07-22       Impact factor: 7.123

Review 7.  Mediterranean Diet on Sleep: A Health Alliance.

Authors:  Egeria Scoditti; Maria Rosaria Tumolo; Sergio Garbarino
Journal:  Nutrients       Date:  2022-07-21       Impact factor: 6.706

8.  Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood.

Authors:  Che-Wei Liao; Chih-Fu Wei; Mei-Huei Chen; Wu-Shiun Hsieh; Ching-Chun Lin; Pau-Chung Chen
Journal:  Front Public Health       Date:  2022-09-30

Review 9.  Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review.

Authors:  Thodur Madapusi Balaji; Saranya Varadarajan; Raghunathan Jagannathan; Jaideep Mahendra; Hammam Ibrahim Fageeh; Hytham N Fageeh; Shazia Mushtaq; Hosam Ali Baeshen; Shilpa Bhandi; Archana A Gupta; A Thirumal Raj; Rodolfo Reda; Shankaragouda Patil; Luca Testarelli
Journal:  Materials (Basel)       Date:  2021-05-06       Impact factor: 3.623
  9 in total

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