Literature DB >> 25705144

DNA electrochemical biosensor for metallic drugs at physiological conditions.

Angel J Santiago-Lopez1, José L Vera2, Enrique Meléndez2.   

Abstract

Entrapment of dsSS-DNA into the polypyrrole-polyvinyl sulphonate (dsSS-DNA-PPy-PVS) film over indium-tin-oxide (ITO) coated glass has been designed to detect titanium and platinum drugs, titanocene dichloride and cisplatin. The disposable dsSS-DNA-PPy-PVS/ITO biosensor was characterized by cyclic voltammetry, attenuated total reflectance Infrared spectroscopy and atomic force microscopy. Amperometric studies by cyclic voltammetry using, dsSS-DNA-PPy PVS/ITO biosensor, demonstrated the ability of this biosensor to detect these metallic drugs in millimolar concentration by monitoring the decrease of the guanine oxidation signal as a result of the DNA damage. The concentration range detected for titanocene dichloride is 0.25 to 1.5 mM and for cisplatin is 0.06 to 1.0 mM.

Entities:  

Keywords:  DNA biosensor; cisplatin; electrochemical detection; electrochemical entrapment; titanocene dichloride

Year:  2014        PMID： 25705144      PMCID： PMC4331038          DOI： 10.1016/j.jelechem.2014.07.022

Source DB:  PubMed          Journal:  J Electroanal Chem (Lausanne)        ISSN： 1572-6657            Impact factor:   4.464


  18 in total

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5.  Titanium(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of the anticancer drug titanocene dichloride.

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9.  Changes in the infrared microspectroscopic characteristics of DNA caused by cationic elements, different base richness and single-stranded form.

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10.  DNA-metallodrugs interactions signaled by electrochemical biosensors: an overview.

Authors:  Mauro Ravera; Graziana Bagni; Marco Mascini; Domenico Osella
Journal:  Bioinorg Chem Appl       Date:  2007       Impact factor: 7.778
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