Arnaud Ferry1,2, Rachid Benchaouir3, Pierre Joanne4, Rachel A Peat5, Nathalie Mougenot6, Onnik Agbulut4, Gillian Butler-Browne1. 1. Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, UMR S794, INSERM, U974, CNRS UMR 7215, Institut de Myologie, Paris, France. 2. Université Paris Descartes, Sorbonne Paris Cité, Paris, France. 3. Université de Versailles Saint Quentin en Yvelines, Inflammation et thérapeutiques, Montigny-le-Bretonneux, France. 4. Université Pierre et Marie Curie 6, Sorbonne Universités, UMR CNRS 8256, Biological Adaptation and Ageing, Paris, France. 5. Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, UMR S956, INSERM, ICAN Institute for Cardiometabolism and Nutrition, Paris, France. 6. Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, PECVM, Paris, France.
Abstract
INTRODUCTION: The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMD(mdx) /J) mice on skeletal and cardiac muscle function have not been studied extensively. METHODS: We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice. RESULTS: We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers. CONCLUSION: These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender.
INTRODUCTION: The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMD(mdx) /J) mice on skeletal and cardiac muscle function have not been studied extensively. METHODS: We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice. RESULTS: We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers. CONCLUSION: These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender.
Authors: Thaís P Gaiad; Murilo X Oliveira; Adalfredo R Lobo; Lívia R Libório; Priscilla A F Pinto; Danielle C Fernandes; Ana Paula Santos; Carlos Eduardo Ambrósio; Alex Sander D Machado Journal: J Exerc Rehabil Date: 2017-12-27