Alessandro Volpe1, Michael L Blute2, Vincenzo Ficarra3, Inderbir S Gill4, Alexander Kutikov5, Francesco Porpiglia6, Craig Rogers7, Karim A Touijer8, Hendrik Van Poppel9, R Houston Thompson10. 1. Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy. Electronic address: alessandro.volpe@med.unipmn.it. 2. Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 3. Division of Urology, Department of Experimental and Clinical Medical Sciences, University of Udine, Italy. 4. Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 5. Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA. 6. Division of Urology, Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy. 7. Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA. 8. Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 9. Department of Urology, Leuven Cancer Institute, Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium. 10. Department of Urology, Mayo Clinic, Rochester, MN, USA.
Abstract
CONTEXT: Partial nephrectomy (PN) is the current gold standard treatment for small localized renal tumors.; however, the impact of duration and type of intraoperative ischemia on renal function (RF) after PN is a subject of significant debate. OBJECTIVE: To review the current evidence on the relationship of intraoperative ischemia and RF after PN. EVIDENCE ACQUISITION: A review of English-language publications on renal ischemia and RF after PN was performed from 2005 to 2014 using the Medline, Embase, and Web of Science databases. Ninety-one articles were selected with the consensus of all authors and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. EVIDENCE SYNTHESIS: The vast majority of reviewed studies were retrospective, nonrandomized observations. Based on the current literature, RF recovery after PN is strongly associated with preoperative RF and the amount of healthy kidney parenchyma preserved. Warm ischemia time (WIT) is modifiable and prolonged warm ischemia is significantly associated with adverse postoperative RF. Available data suggest a benefit of keeping WIT <25min, although the level of evidence to support this threshold is limited. Cold ischemia safely facilitates longer durations of ischemia. Surgical techniques that minimize or avoid global ischemia may be associated with improved RF outcomes. CONCLUSIONS: Although RF recovery after PN is strongly associated with quality and quantity of preserved kidney, efforts should be made to limit prolonged WIT. Cold ischemia should be preferred when longer ischemia is expected, especially in presence of imperative indications for PN. Additional research with higher levels of evidence is needed to clarify the optimal use of renal ischemia during PN. PATIENT SUMMARY: In this review of the literature, we looked at predictors of renal function after surgical resection of renal tumors. There is a strong association between the quality and quantity of renal tissue that is preserved after surgery and long-term renal function. The time of interruption of renal blood flow during surgery is an important, modifiable predictor of postoperative renal function.
CONTEXT: Partial nephrectomy (PN) is the current gold standard treatment for small localized renal tumors.; however, the impact of duration and type of intraoperative ischemia on renal function (RF) after PN is a subject of significant debate. OBJECTIVE: To review the current evidence on the relationship of intraoperative ischemia and RF after PN. EVIDENCE ACQUISITION: A review of English-language publications on renal ischemia and RF after PN was performed from 2005 to 2014 using the Medline, Embase, and Web of Science databases. Ninety-one articles were selected with the consensus of all authors and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. EVIDENCE SYNTHESIS: The vast majority of reviewed studies were retrospective, nonrandomized observations. Based on the current literature, RF recovery after PN is strongly associated with preoperative RF and the amount of healthy kidney parenchyma preserved. Warm ischemia time (WIT) is modifiable and prolonged warm ischemia is significantly associated with adverse postoperative RF. Available data suggest a benefit of keeping WIT <25min, although the level of evidence to support this threshold is limited. Cold ischemia safely facilitates longer durations of ischemia. Surgical techniques that minimize or avoid global ischemia may be associated with improved RF outcomes. CONCLUSIONS: Although RF recovery after PN is strongly associated with quality and quantity of preserved kidney, efforts should be made to limit prolonged WIT. Cold ischemia should be preferred when longer ischemia is expected, especially in presence of imperative indications for PN. Additional research with higher levels of evidence is needed to clarify the optimal use of renal ischemia during PN. PATIENT SUMMARY: In this review of the literature, we looked at predictors of renal function after surgical resection of renal tumors. There is a strong association between the quality and quantity of renal tissue that is preserved after surgery and long-term renal function. The time of interruption of renal blood flow during surgery is an important, modifiable predictor of postoperative renal function.
Authors: Zeynep Gul; Kyle A Blum; David J Paulucci; Ronney Abaza; Daniel D Eun; Akshay Bhandari; Ashok K Hemal; James Porter; Ketan K Badani Journal: J Robot Surg Date: 2018-10-12
Authors: Steven M Monda; Jonathan R Weese; Barrett G Anderson; Joel M Vetter; Ramakrishna Venkatesh; Kefu Du; Gerald L Andriole; Robert S Figenshau Journal: Urology Date: 2018-02-05 Impact factor: 2.649