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Literature DB >> 2570349

The Klebsiella pneumoniae PII protein (glnB gene product) is not absolutely required for nitrogen regulation and is not involved in NifL-mediated nif gene regulation.

Abstract

The role of the Klebsiella pneumoniae PII protein (encoded by glnB) in nitrogen regulation has been studied using two classes of glnB mutants. In Class I mutants PII appears not to be uridylylated in nitrogen-limiting conditions and in Class II mutants PII is not synthesised. The effects of these mutations on expression from nitrogen-regulated promoters indicate that PII is not absolutely required for nitrogen control. Furthermore the uridylylated form of PII (PII-UMP) plays a significant role in the response to changes in nitrogen status by counteracting the effect of PII on NtrB-mediated dephosphorylation of NtrC. PII is not involved in the nif-specific response to changes in nitrogen status mediated by NifL.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1989 PMID： 2570349 DOI： 10.1007/BF02464920

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

30 in total

1. Regulation of the synthesis of glutamine synthetase by the PII protein in Klebsiella aerogenes.

Authors: F Foor; Z Reuveny; B Magasanik
Journal: Proc Natl Acad Sci U S A Date: 1980-05 Impact factor: 11.205

2. Analysis of the Klebsiella pneumoniae ntrB gene by site-directed in vitro mutagenesis.

Authors: S A MacFarlane; M J Merrick
Journal: Mol Microbiol Date: 1987-09 Impact factor: 3.501

3. Positive control and autogenous regulation of the nifLA promoter in Klebsiella pneumoniae.

Authors: M Drummond; J Clements; M Merrick; R Dixon
Journal: Nature Date: 1983-01-27 Impact factor: 49.962

4. Interaction of purified NtrC protein with nitrogen regulated promoters from Klebsiella pneumoniae.

Authors: T Hawkes; M Merrick; R Dixon
Journal: Mol Gen Genet Date: 1985

5. Glutamine synthetase and the regulation of histidase formation in Klebsiella aerogenes.

Authors: M J Prival; J E Brenchley; B Magasanik
Journal: J Biol Chem Date: 1973-06-25 Impact factor: 5.157

6. Regulation of the synthesis of enzymes responsible for glutamate formation in Klebsiella aerogenes.

Authors: J E Brenchley; M J Prival; B Magasanik
Journal: J Biol Chem Date: 1973-09-10 Impact factor: 5.157

7. Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC.

Authors: B T Nixon; C W Ronson; F M Ausubel
Journal: Proc Natl Acad Sci U S A Date: 1986-10 Impact factor: 11.205

8. Sequence of nifL from Klebsiella pneumoniae: mode of action and relationship to two families of regulatory proteins.

Authors: M H Drummond; J C Wootton
Journal: Mol Microbiol Date: 1987-07 Impact factor: 3.501

9. Sequence and domain relationships of ntrC and nifA from Klebsiella pneumoniae: homologies to other regulatory proteins.

Authors: M Drummond; P Whitty; J Wootton
Journal: EMBO J Date: 1986-02 Impact factor: 11.598

10. Positive and negative control of the glnA ntrBC regulon in Klebsiella pneumoniae.

Authors: A Alvarez-Morales; R Dixon; M Merrick
Journal: EMBO J Date: 1984-03 Impact factor: 11.598

17 in total

Review 1. P(II) signal transduction proteins, pivotal players in microbial nitrogen control.

Authors: T Arcondéguy; R Jack; M Merrick
Journal: Microbiol Mol Biol Rev Date: 2001-03 Impact factor: 11.056

2. Nutrient-dependent methylation of a membrane-associated protein of Escherichia coli.

Authors: C C Young; J D Alvarez; R W Bernlohr
Journal: J Bacteriol Date: 1990-09 Impact factor: 3.490

3. Structure/function analysis of the PII signal transduction protein of Escherichia coli: genetic separation of interactions with protein receptors.

Authors: P Jiang; P Zucker; M R Atkinson; E S Kamberov; W Tirasophon; P Chandran; B R Schefke; A J Ninfa
Journal: J Bacteriol Date: 1997-07 Impact factor: 3.490

4. Characterization of Azorhizobium caulinodans glnB and glnA genes: involvement of the P(II) protein in symbiotic nitrogen fixation.

Authors: N Michel-Reydellet; N Desnoues; C Elmerich; P A Kaminski
Journal: J Bacteriol Date: 1997-06 Impact factor: 3.490

5. The product of the nitrogen fixation regulatory gene nfrX of Azotobacter vinelandii is functionally and structurally homologous to the uridylyltransferase encoded by glnD in enteric bacteria.

Authors: A Contreras; M Drummond; A Bali; G Blanco; E Garcia; G Bush; C Kennedy; M Merrick
Journal: J Bacteriol Date: 1991-12 Impact factor: 3.490

6. Cloning of Azorhizobium caulinodans nicotinate catabolism genes and characterization of their importance in N2 fixation.

Authors: L M Buckmiller; J P Lapointe; R A Ludwig
Journal: J Bacteriol Date: 1991-03 Impact factor: 3.490

7. The role of uridylyltransferase in the control of Klebsiella pneumoniae nif gene regulation.

Authors: R Edwards; M Merrick
Journal: Mol Gen Genet Date: 1995-04-20

8. The signal transduction protein GlnK is required for NifL-dependent nitrogen control of nif gene expression in Klebsiella pneumoniae.

Authors: R Jack; M De Zamaroczy; M Merrick
Journal: J Bacteriol Date: 1999-02 Impact factor: 3.490

9. Functional organization of the glnB-glnA cluster of Azospirillum brasilense.

Authors: M de Zamaroczy; A Paquelin; C Elmerich
Journal: J Bacteriol Date: 1993-05 Impact factor: 3.490

10. Physiological role for the GlnK protein of enteric bacteria: relief of NifL inhibition under nitrogen-limiting conditions.

Authors: L He; E Soupene; A Ninfa; S Kustu
Journal: J Bacteriol Date: 1998-12 Impact factor: 3.490