Delia Fahrendorf1, Volker Hesselmann2, Wolfram Schwindt1, Johannes Wölfer3, Astrid Jeibmann4, Hendrik Kooijman1, Harald Kugel5, Walter Heindel1, Andrea Bink6. 1. Department of Clinical Radiology, University Hospital Münster, Münster, Germany. 2. Department of Neuroradiology, Asklepios Clinic Nord-Heidberg, Hamburg, Germany. 3. Department of Neurosurgery, University Hospital Münster, Münster, Germany. 4. Institute of Neuropathology, University Hospital Münster, Münster, Germany. 5. Philips Healthcare, Clinical Application, Lübeckertordamm, Hamburg, Germany. 6. Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, University Hospital Basel.
Abstract
BACKGROUND: Susceptibility weighted imaging and assessment of intratumoral susceptibility signal (ITSS) morphology is used to identify high-grade glioma (HGG) in patients with suspected brain neoplasm. PURPOSE: The aim of this study was to outline variations in ITSS-morphology and their relationship to location as well as volume of the lesion in patients with glioblastoma (GB). MATERIALS AND METHODS: Contrast-enhanced SWI (CE-SWI) images of 40 patients with histologically confirmed GB were analyzed retrospectively with particular attention to ITSS-morphology dividing all lesions into two groups. Considering the location of the lesion within brain parenchyma, lesions with and without involvement of the subventricular zone (SVZ+/SVZ-) were discerned. Additionally, the contrast-enhancing tumor volume was evaluated. Statistical analysis was based on a classification analysis resulting in a classification rule (tree) as well as Mann-Whitney-U test. RESULTS: The distribution of ITSS-scores showed differences between the SVZ+ and SVZ- groups. While SVZ-GB showed only fine-linear or dot-like ITSS, in SVZ+ GB the ITSS-morphology changed with the tumor volume, that is, in larger tumors dense and conglomerated ITSS were the predominant finding. CONCLUSION: Our findings indicate that ITSS-morphology is not a random phenomenon. Location of GB, as well as tumor volume, appear to be factors contributing to ITSS morphology.
BACKGROUND: Susceptibility weighted imaging and assessment of intratumoral susceptibility signal (ITSS) morphology is used to identify high-grade glioma (HGG) in patients with suspected brain neoplasm. PURPOSE: The aim of this study was to outline variations in ITSS-morphology and their relationship to location as well as volume of the lesion in patients with glioblastoma (GB). MATERIALS AND METHODS: Contrast-enhanced SWI (CE-SWI) images of 40 patients with histologically confirmed GB were analyzed retrospectively with particular attention to ITSS-morphology dividing all lesions into two groups. Considering the location of the lesion within brain parenchyma, lesions with and without involvement of the subventricular zone (SVZ+/SVZ-) were discerned. Additionally, the contrast-enhancing tumor volume was evaluated. Statistical analysis was based on a classification analysis resulting in a classification rule (tree) as well as Mann-Whitney-U test. RESULTS: The distribution of ITSS-scores showed differences between the SVZ+ and SVZ- groups. While SVZ-GB showed only fine-linear or dot-like ITSS, in SVZ+ GB the ITSS-morphology changed with the tumor volume, that is, in larger tumors dense and conglomerated ITSS were the predominant finding. CONCLUSION: Our findings indicate that ITSS-morphology is not a random phenomenon. Location of GB, as well as tumor volume, appear to be factors contributing to ITSS morphology.
Authors: Akshitkumar M Mistry; Michael C Dewan; Gabrielle A White-Dzuro; Philip R Brinson; Kyle D Weaver; Reid C Thompson; Rebecca A Ihrie; Lola B Chambless Journal: J Neurooncol Date: 2017-01-10 Impact factor: 4.130
Authors: Akshitkumar M Mistry; Andrew T Hale; Lola B Chambless; Kyle D Weaver; Reid C Thompson; Rebecca A Ihrie Journal: J Neurooncol Date: 2016-09-19 Impact factor: 4.130
Authors: Joshua D Bernstock; Sam E Gary; Neil Klinger; Pablo A Valdes; Walid Ibn Essayed; Hannah E Olsen; Gustavo Chagoya; Galal Elsayed; Daisuke Yamashita; Patrick Schuss; Florian A Gessler; Pier Paolo Peruzzi; Asim K Bag; Gregory K Friedman Journal: Neurooncol Adv Date: 2022-05-26