| Literature DB >> 25702849 |
Christopher R M Asquith1, Marina L Meli2, Lidia S Konstantinova3, Tuomo Laitinen4, Antti Poso4, Oleg A Rakitin3, Regina Hofmann-Lehmann2, Karin Allenspach5, Stephen T Hilton6.
Abstract
A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection. CrownEntities:
Keywords: FIV; HIV; Nucleocapsid; Tetrathiocenes; Zinc finger
Mesh：
Substances：
Year: 2014 PMID： 25702849 DOI： 10.1016/j.bmcl.2014.12.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823