Literature DB >> 2570150

(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.

R D Clark1, D B Repke, A T Kilpatrick, C M Brown, A C MacKinnon, R U Clague, M Spedding.   

Abstract

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Year:  1989        PMID： 2570150     DOI： 10.1021/jm00129a002

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  8 in total

1.  Modelling of adrenoceptor ligand targets based on novel medium- or macro-sized fused nitrogen heterocyclic systems.

Authors:  R Griffith; J B Bremner
Journal:  J Comput Aided Mol Des       Date:  1999-01       Impact factor: 3.686

2.  The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist.

Authors:  C A Halliday; B J Jones; M Skingle; D M Walsh; H Wise; M B Tyers
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

3.  Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.

Authors:  Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal:  ACS Comb Sci       Date:  2011-11-10       Impact factor: 3.784

4.  A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat.

Authors:  W S Redfern; A Williams
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

5.  The pharmacology of RS-15385-197, a potent and selective alpha 2-adrenoceptor antagonist.

Authors:  C M Brown; A C MacKinnon; W S Redfern; P E Hicks; A T Kilpatrick; C Small; M Ramcharan; R U Clague; R D Clark; C B MacFarlane
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

6.  Modulation of central noradrenergic function by RS-15385-197.

Authors:  W S Redfern; A C MacKinnon; C M Brown; A B Martin; A T Kilpatrick; R U Clague; M Spedding
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

7.  [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification.

Authors:  A C MacKinnon; A T Kilpatrick; B A Kenny; M Spedding; C M Brown
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

8.  Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197).

Authors:  D Tallentire; G McRae; M Spedding; R Clark; B Vickery
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739
  8 in total

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