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Literature DB >> 25700834

The role of STAT3 in tumor-mediated immune suppression.

Sherise D Ferguson¹, Visish M Srinivasan, Amy B Heimberger.

Abstract

The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25700834 DOI： 10.1007/s11060-015-1731-3

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

72 in total

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28 in total

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Journal: Proc Natl Acad Sci U S A Date: 2018-02-20 Impact factor: 11.205

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