YuSong Ding1, ShuGang Li1, Ru-Lin Ma2, Heng Guo2, JingYu Zhang2, Mei Zhang2, JiaMing Liu2, ShuXia Guo3. 1. Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China; Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China. 2. Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China. 3. Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China; Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China. Electronic address: 51603030@qq.com.
Abstract
OBJECTIVE: We examined the association between insulin resistance (IR), adiponectin, and inflammation markers and the development of metabolic syndrome (MetS). Furthermore, we aimed to establish the relationship between IR, serum adiponectin, and parameters of chronic inflammation. METHODS: MetS was assessed in 1628 Kazakh participants (768 men; 860 women) in Xinjiang, Northwestern China. RESULTS: Adiponectin, homeostasis model assessment of IR (HOMA-IR), interleukin-6 (IL-6), and C-reactive protein (CRP) remained significantly associated with MetS after further adjustment for sex, age, smoking status, low-density lipoprotein cholesterol, total cholesterol, and high-density lipoprotein cholesterol. Moreover, HOMA-IR, IL-6, and CRP increased concurrently with an increased number of MetS components, and an inverse trend between adiponectin and increased number of MetS components was found. The median of IL-6 and CRP increased with HOMA-IR from the lowest to the highest quartile. In contrast, the median of adiponectin remarkably decreased with HOMA-IR from the lowest to the highest quartile (P<0.001). According to multiple linear regression analysis, adiponectin, CRP, and IL-6 also showed a significant association with HOMA-IR. CONCLUSION: We strengthen the notion that HOMA-IR, adiponectin, and inflammatory markers can predict the course of MetS. Furthermore, our results suggest that a chronic state of inflammation and decreased serum adiponectin might be associated with IR.
OBJECTIVE: We examined the association between insulin resistance (IR), adiponectin, and inflammation markers and the development of metabolic syndrome (MetS). Furthermore, we aimed to establish the relationship between IR, serum adiponectin, and parameters of chronic inflammation. METHODS: MetS was assessed in 1628 Kazakh participants (768 men; 860 women) in Xinjiang, Northwestern China. RESULTS:Adiponectin, homeostasis model assessment of IR (HOMA-IR), interleukin-6 (IL-6), and C-reactive protein (CRP) remained significantly associated with MetS after further adjustment for sex, age, smoking status, low-density lipoprotein cholesterol, total cholesterol, and high-density lipoprotein cholesterol. Moreover, HOMA-IR, IL-6, and CRP increased concurrently with an increased number of MetS components, and an inverse trend between adiponectin and increased number of MetS components was found. The median of IL-6 and CRP increased with HOMA-IR from the lowest to the highest quartile. In contrast, the median of adiponectin remarkably decreased with HOMA-IR from the lowest to the highest quartile (P<0.001). According to multiple linear regression analysis, adiponectin, CRP, and IL-6 also showed a significant association with HOMA-IR. CONCLUSION: We strengthen the notion that HOMA-IR, adiponectin, and inflammatory markers can predict the course of MetS. Furthermore, our results suggest that a chronic state of inflammation and decreased serum adiponectin might be associated with IR.
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