| Literature DB >> 25699577 |
Yuji Kawato1, Akino Kubota, Hiromi Ono, Hiromichi Egami, Yoshitaka Hamashima.
Abstract
A highly enantioselective bromocyclization of allylic amides with N-bromosuccinimide (NBS) was developed with DTBM-BINAP as a catalyst, affording chiral oxazolines with a tetrasubstituted carbon center in high yield with up to 99% ee. By utilizing the bromo substituent as a handle, the obtained compounds were converted to synthetically useful chiral building blocks.Entities:
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Year: 2015 PMID： 25699577 DOI： 10.1021/acs.orglett.5b00220
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005