| Literature DB >> 25699574 |
Meri Emili F Pinto1, João M Batista1,2, Johannes Koehbach3,4, Pratibha Gaur5, Abhinay Sharma5, Myna Nakabashi5, Eduardo Maffud Cilli1, Guilherme M Giesel6, Hugo Verli6, Christian W Gruber4, Ewan W Blanch2, Joseam F Tavares7, Marcelo S da Silva7, Celia R S Garcia5, Vanderlan S Bolzani1.
Abstract
A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 μM) against the Plasmodium falciparum strain 3D7.Entities:
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Year: 2015 PMID： 25699574 DOI： 10.1021/np5007668
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050