Literature DB >> 25699144

Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.

Kevin T O'Brien1, Joseph G Noto1, Luke Nichols-O'Neill1, Lark J Perez1.   

Abstract

Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.

Entities:  

Keywords:  Pseudomonas aeruginosa; antivirulence; biofilm inhibition; quorum sensing; structure−activity relationship

Year:  2014        PMID： 25699144      PMCID： PMC4329587          DOI： 10.1021/ml500459f

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  33 in total

Review 1.  Mechanisms of antibiotic resistance in Pseudomonas aeruginosa.

Authors:  P A Lambert
Journal:  J R Soc Med       Date:  2002       Impact factor: 5.344

2.  LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters.

Authors:  Gerhard Wolber; Thierry Langer
Journal:  J Chem Inf Model       Date:  2005 Jan-Feb       Impact factor: 4.956

3.  Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing.

Authors:  Grant D Geske; Jennifer C O'Neill; David M Miller; Rachel J Wezeman; Margrith E Mattmann; Qi Lin; Helen E Blackwell
Journal:  Chembiochem       Date:  2008-02-15       Impact factor: 3.164

Review 4.  Anti-virulence strategies to combat bacteria-mediated disease.

Authors:  David A Rasko; Vanessa Sperandio
Journal:  Nat Rev Drug Discov       Date:  2010-01-18       Impact factor: 84.694

5.  Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum.

Authors:  Joseph S Zakhari; Isao Kinoyama; Anjali K Struss; Prasanna Pullanikat; Colin A Lowery; Matthew Lardy; Kim D Janda
Journal:  J Am Chem Soc       Date:  2011-02-24       Impact factor: 15.419

6.  A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Authors:  Ute Müh; Brian J Hare; Breck A Duerkop; Martin Schuster; Brian L Hanzelka; Roger Heim; Eric R Olson; E Peter Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-30       Impact factor: 11.205

7.  Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.

Authors:  Yaozhong Zou; Satish K Nair
Journal:  Chem Biol       Date:  2009-09-25

8.  Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.

Authors:  J P Pearson; K M Gray; L Passador; K D Tucker; A Eberhard; B H Iglewski; E P Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

9.  Covalent inhibition of bacterial quorum sensing.

Authors:  Neri Amara; Roi Mashiach; Dotan Amar; Pnina Krief; Stéphane A H Spieser; Matthew J Bottomley; Amir Aharoni; Michael M Meijler
Journal:  J Am Chem Soc       Date:  2009-08-05       Impact factor: 15.419

10.  SwissDock, a protein-small molecule docking web service based on EADock DSS.

Authors:  Aurélien Grosdidier; Vincent Zoete; Olivier Michielin
Journal:  Nucleic Acids Res       Date:  2011-05-29       Impact factor: 16.971
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  14 in total

1.  Molecular Insights into the Impact of Oxidative Stress on the Quorum-Sensing Regulator Protein LasR.

Authors:  Prapti Kafle; Amanda N Amoh; Jocelyn M Reaves; Emma G Suneby; Kathryn A Tutunjian; Reed L Tyson; Tanya L Schneider
Journal:  J Biol Chem       Date:  2016-04-06       Impact factor: 5.157

Review 2.  Chemical probes of quorum sensing: from compound development to biological discovery.

Authors:  Michael A Welsh; Helen E Blackwell
Journal:  FEMS Microbiol Rev       Date:  2016-06-05       Impact factor: 16.408

3.  The Rhl Quorum-Sensing System Is at the Top of the Regulatory Hierarchy under Phosphate-Limiting Conditions in Pseudomonas aeruginosa PAO1.

Authors:  Martín Paolo Soto-Aceves; Miguel Cocotl-Yañez; Luis Servín-González; Gloria Soberón-Chávez
Journal:  J Bacteriol       Date:  2021-02-08       Impact factor: 3.490

4.  Pseudomonas aeruginosa Quorum Sensing.

Authors:  Samantha Wellington Miranda; Kyle L Asfahl; Ajai A Dandekar; E P Greenberg
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

5.  Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.

Authors:  Matthew C O'Reilly; Shi-Hui Dong; Francis M Rossi; Kaleigh M Karlen; Rohan S Kumar; Satish K Nair; Helen E Blackwell
Journal:  Cell Chem Biol       Date:  2018-07-19       Impact factor: 8.116

Review 6.  Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa.

Authors:  Taehyeong Lim; So-Young Ham; SangJin Nam; Myoungsun Kim; Ki Yong Lee; Hee-Deung Park; Youngjoo Byun
Journal:  Antibiotics (Basel)       Date:  2022-02-19

7.  Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G.

Authors:  Morgan A Hitchner; Matthew R Necelis; Devanie Shirley; Gregory A Caputo
Journal:  Probiotics Antimicrob Proteins       Date:  2021-04       Impact factor: 4.609

8.  High-Throughput Virtual Screening for a New Class of Antagonist Targeting LasR of Pseudomonas aeruginosa.

Authors:  Aishwarya Vetrivel; Santhi Natchimuthu; Vidyalakshmi Subramanian; Rajeswari Murugesan
Journal:  ACS Omega       Date:  2021-07-08

9.  A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design.

Authors:  Joseph D Moore; Francis M Rossi; Michael A Welsh; Kayleigh E Nyffeler; Helen E Blackwell
Journal:  J Am Chem Soc       Date:  2015-11-11       Impact factor: 15.419

10.  Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor.

Authors:  Matthew C O'Reilly; Helen E Blackwell
Journal:  ACS Infect Dis       Date:  2015-11-02       Impact factor: 5.084
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