| Literature DB >> 25697264 |
Osamu Nunobiki1, Masatsugu Ueda, Hikari Akise, Shinji Izuma, Kiyo Torii, Yoshiaki Okamoto, Ichiro Tanaka, Sadamu Noda, Kyoko Akashi, Taro Higashida.
Abstract
The aim of the study is to investigate the clinical significance of glutathione-S-transferase GSTM1, GSTT1, and NQO1 c.609C>T (rs1800566) genetic polymorphisms in cervical carcinogenesis. GSTM1, GSTT1, and NQO1 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 192 cervical smear in exfoliated cervical cell samples using polymerase chain reaction (PCR) system and real-time polymerase chain reaction (PCR) system. The 19 patients with high-grade squamous intraepithelial lesion had statistically higher frequency of null GSTT1 genotype than 9 with low-grade squamous intraepithelial lesion (LSIL) among the 67 patients with high-risk HPV (P = 0.024). The 24 patients with HSIL had also statistically higher frequency of NQO1 (CT+TT) genotype than 14 with LSIL among the 67 patients with high-risk HPV (P = 0.024). GSTT1 null and NQO1 genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25697264 DOI： 10.1007/s13577-015-0111-9
Source DB: PubMed Journal: Hum Cell ISSN： 0914-7470 Impact factor: 4.174