[The influence of testosterone and β-estradiol on T-lymphocytes activation associated with IL-2 production and expression of CD25 (IL-2Rα) molecules].

We have shown that testosterone and β-estradiol in vitro have effects on naïve (CD45RA+) and priming (CD45RO+) T-lymphocytes, which associated with the production of IL-2 and CD25/IL-2Rα expression. Testosterone can inhibit naïve and priming T-cell function activity in our study. Moreover it was shown that naïve lymphocytes are more sensitive to testosterone than primed. We have found dose dependent suppressive β-estradiol effect on IL-2 production by activated CD45RA+ and CD45RO+ lymphocytes which leads to uniform decreasing CD25-positive T-cells number.