Literature DB >> 25696875

What is the effect of rivaroxaban on routine coagulation tests?

Deborah M Siegal1, Barbara A Konkle1.   

Abstract

A 78-year-old female presents to the emergency department with a traumatic hip fracture. Her past medical history is significant for atrial fibrillation for which she receives rivaroxaban 20 mg daily. Her dose was last taken 12 hours ago. Routine bloodwork conducted in the emergency department shows prothrombin time, international normalized ratio, and activated partial thromboplastin time within the normal range, and estimated glomerular filtration rate of 50 mL/min/1.73 m(2) (normal is >90 mL/min/1.73 m(2)) You are asked by the surgical team to confirm that it is safe to proceed with surgery at this time using neuraxial anesthesia.
© 2014 by The American Society of Hematology. All rights reserved.

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Year:  2014        PMID: 25696875     DOI: 10.1182/asheducation-2014.1.334

Source DB:  PubMed          Journal:  Hematology Am Soc Hematol Educ Program        ISSN: 1520-4383


  2 in total

1.  Standard coagulation assays alone are not sufficient to exclude surgically relevant rivaroxaban plasma concentrations.

Authors:  Alexander Kaserer; Andreas Schedler; Burkhardt Seifert; Donat R Spahn; Jan-Dirk Studt; Philipp Stein
Journal:  Perioper Med (Lond)       Date:  2019-11-20

2.  Elderly people are inherently sensitive to the pharmacological activity of rivaroxaban: implications for DOAC prescribing.

Authors:  Emmanouela Kampouraki; Salah Abohelaika; Peter Avery; Tina Biss; Paul Murphy; Hilary Wynne; Farhad Kamali
Journal:  J Thromb Thrombolysis       Date:  2020-11-01       Impact factor: 2.300

  2 in total

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