Antonio Cabrera de León1, José Gregorio Oliva García2, Itahisa Marcelino Rodríguez3, Delia Almeida González4, José Juan Alemán Sánchez3, Buenaventura Brito Díaz3, Santiago Domínguez Coello3, Vicente Bertomeu Martínez5, Armando Aguirre Jaime6, María del Cristo Rodríguez Pérez3. 1. Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain University of La Laguna, La Laguna, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain acableo@gobiernodecanarias.org. 2. Endocrine Diseases Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain. 3. Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain Cardiovascular Research Network of the Carlos III Institute of Health, Spain. 4. Cardiovascular Research Network of the Carlos III Institute of Health, Spain Immunology Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain. 5. Cardiovascular Research Network of the Carlos III Institute of Health, Spain Servicio de Cardiología, Hospital San Juan, Universidad Miguel Hernández, Alicante, Spain. 6. Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain.
Abstract
OBJECTIVE: To analyse the association between serum C-peptide and coronary artery disease in the general population. METHODS: Follow-up study of 6630 adults from the general population. They were stratified into group 1 (no insulin resistance: C-peptide < third tercile and glycaemia < 100 mg/dL), group 2 (initial insulin resistance: C-peptide ⩾ third tercile and glycaemia < 100 mg/dL) and group 3 (advanced insulin resistance: glycaemia ⩾ 100 mg/dL). RESULTS: After 3.5 years of follow-up, group 2 had a higher incidence of myocardial infarction (relative risk (RR) = 4.2, 95% confidence interval (CI) = 1.7-10.6) and coronary artery disease (RR = 3.5, 95% CI = 1.9-6.6) than group 1. Group 3 also had increased incidences of both diseases. In multivariable analysis of the entire population, groups 2 and 3 showed significant risks of myocardial infarction and coronary artery disease (RR > 3 and RR > 2, respectively). However, when people with diabetes were excluded, the increased risks were corroborated only in group 2 for myocardial infarction (RR = 2.8, 95% CI = 1.1-6.9; p = 0.025) and coronary artery disease (RR = 2.4, 95% CI = 1.3-4.6; p = 0.007). CONCLUSION: Elevated C-peptide is associated with the incidence of myocardial infarction and coronary artery disease in the general population. It can be an earlier predictor of coronary events than impaired fasting glucose.
OBJECTIVE: To analyse the association between serum C-peptide and coronary artery disease in the general population. METHODS: Follow-up study of 6630 adults from the general population. They were stratified into group 1 (no insulin resistance: C-peptide < third tercile and glycaemia < 100 mg/dL), group 2 (initial insulin resistance: C-peptide ⩾ third tercile and glycaemia < 100 mg/dL) and group 3 (advanced insulin resistance: glycaemia ⩾ 100 mg/dL). RESULTS: After 3.5 years of follow-up, group 2 had a higher incidence of myocardial infarction (relative risk (RR) = 4.2, 95% confidence interval (CI) = 1.7-10.6) and coronary artery disease (RR = 3.5, 95% CI = 1.9-6.6) than group 1. Group 3 also had increased incidences of both diseases. In multivariable analysis of the entire population, groups 2 and 3 showed significant risks of myocardial infarction and coronary artery disease (RR > 3 and RR > 2, respectively). However, when people with diabetes were excluded, the increased risks were corroborated only in group 2 for myocardial infarction (RR = 2.8, 95% CI = 1.1-6.9; p = 0.025) and coronary artery disease (RR = 2.4, 95% CI = 1.3-4.6; p = 0.007). CONCLUSION: Elevated C-peptide is associated with the incidence of myocardial infarction and coronary artery disease in the general population. It can be an earlier predictor of coronary events than impaired fasting glucose.
Authors: Hala B AlEssa; Vasanti S Malik; Changzheng Yuan; Walter C Willett; Tianyi Huang; Frank B Hu; Deirdre K Tobias Journal: Am J Clin Nutr Date: 2016-12-14 Impact factor: 7.045
Authors: Amanda L Missel; Laura R Saslow; Dina H Griauzde; Donna Marvicsin; Ananda Sen; Caroline R Richardson; Xuefeng Liu Journal: Diabetol Metab Syndr Date: 2021-03-10 Impact factor: 3.320