| Literature DB >> 25695160 |
Carola Heneweer1, Markus Siggelkow2, Michael Helle3, Rainer Petzina2, Asmus Wulff1, Joost P Schaefer1, Rouven Berndt2, Rene Rusch2, Thilo Wedel4, Guenther Klaws4, Magdalena Müller-Gerbl5, Christoph Röcken6, Olav Jansen1, Georg Lutter2, Joachim Cremer2, Justus Groß2.
Abstract
Stenosis and occlusion of the superficial femoral artery (SFA) are most common in arterial occlusive disease. There are numerous interventional, surgical, and combined approaches to reconstitute maximum blood supply to the lower limb; however, despite intense clinical research, the long-term success rates are still poor. We present the first results with a catheter prototype for laser-based minimal invasive endarterectomy, called laser scoop desobliteration (LSD). The tip of a glass fiber containing a catheter was modified with a spatula head design and connected to an ultraviolet laser. It was tested in cadavers fixed with the Thiel embalming technique preserving tissue consistency, flexibility, and plasticity. After longitudinal arteriotomy of the SFA, a circular dissection between media and adventitia was performed. Then the LSD catheter was inserted and propagated with a progress of 1 mm∕s. Afterward, the atheroma core, which showed a plain surface without substantial attaching tissue debris, was removed. Histological examination of the vessel wall showed that the dissection was performed at the media/adventitia interface. In summary, the constructed LSD catheter allowed a rapid and easy way to perform an endarterectomy, thereby offering an innovative approach in the treatment of chronic occluded SFA.Entities:
Mesh:
Year: 2015 PMID: 25695160 DOI: 10.1117/1.JBO.20.2.025005
Source DB: PubMed Journal: J Biomed Opt ISSN: 1083-3668 Impact factor: 3.170