Literature DB >> 25694767

A unique case of ruptured ectopic pregnancy in a patient with negative preg-nancy test - a case report and brief review of the literature.

A Daniilidis1, A Pantelis1, V Makris1, D Balaouras1, N Vrachnis2.   

Abstract

INTRODUCTION: Despite the major advances made in the diagnosis and management of ectopic pregnancies in the last two decades, an accurate diagnosis can sometimes still be quite challenging, since it relies on the combination of ultrasound findings and serial serum beta-human chorionic gonadotrophin (β-hCG) measurements. CASE
PRESENTATION: This paper describes the case of a 36-year-old woman of Caucasian origin who was admitted to the emergency department of our clinic with clinical symptoms of hemorrhagic shock in combination with two negative pregnancy tests done by her at home and a negative urine test which was performed on her admission to the hospital. Quantitative measurement of β-hCG in the serum of the patient was 13 mIU/mL. On admission, right tubal pregnancy was diagnosed on ultrasound and she underwent an emergency laparotomy due to signs of hemodynamic shock.
CONCLUSION: It is sometimes a considerable challenge to identify a patient with an ectopic pregnancy at risk of rupture. This case of ectopic pregnancy which was followed by a negative pregnancy test illustrates the magnitude of the difficulties involved in the diagnosis of ectopic pregnancy. It also demonstrates the need to maintain a high clinical index of suspicion and to undertake careful clinical examination of the patient on the basis of the clinician's diagnostic research. Hippokratia 2014; 18 (3): 282-284.

Entities:  

Keywords:  Ectopic pregnancy; beta human chorionic gonadotrophin; hemorrhagic shock; β-hCG

Year:  2014        PMID: 25694767      PMCID: PMC4309153     

Source DB:  PubMed          Journal:  Hippokratia        ISSN: 1108-4189            Impact factor:   0.471


  17 in total

1.  Negative betahCG: positive ectopic pregnancy.

Authors:  Adrian Skinner; Peter Jones
Journal:  N Z Med J       Date:  2003-10-10

2.  Pregnancy of unknown viability or location: less is more in the majority of cases.

Authors:  Nick Raine-Fenning; Shyamaly Sur; Andrew W Horne; Helen Wilkinson; Tom Bourne
Journal:  J Fam Plann Reprod Health Care       Date:  2012-01

Review 3.  Saving Mothers' Lives (formerly Why Mothers die): reviewing maternal deaths to make motherhood safer 2003-2005.

Authors:  Rosemary Mander; Graeme D Smith
Journal:  Midwifery       Date:  2008-02-20       Impact factor: 2.372

Review 4.  Current knowledge of the aetiology of human tubal ectopic pregnancy.

Authors:  J L V Shaw; S K Dey; H O D Critchley; A W Horne
Journal:  Hum Reprod Update       Date:  2010-01-12       Impact factor: 15.610

5.  Ectopic pregnancy with undetectable serum and urine beta-hCG levels and detection of beta-hCG in the ectopic trophoblast by immunocytochemical evaluation.

Authors:  M L Maccato; R Estrada; S Faro
Journal:  Obstet Gynecol       Date:  1993-05       Impact factor: 7.661

6.  Saving mothers' lives. Reviewing maternal deaths to make motherhood safer: 2006-2008.

Authors:  Helen Wilkinson
Journal:  BJOG       Date:  2011-10       Impact factor: 6.531

Review 7.  The need for serum biomarker development for diagnosing and excluding tubal ectopic pregnancy.

Authors:  Andrew W Horne; W Colin Duncan; Hilary Od Critchley
Journal:  Acta Obstet Gynecol Scand       Date:  2010-03       Impact factor: 3.636

8.  Ectopic pregnancy with shock and undetectable beta-human chorionic gonadotropin. A case report.

Authors:  N M Lonky; M V Sauer
Journal:  J Reprod Med       Date:  1987-07       Impact factor: 0.142

9.  Hemorrhagic shock from a ruptured ectopic pregnancy in a patient with a negative urine pregnancy test result.

Authors:  Michelle A Kalinski; David A Guss
Journal:  Ann Emerg Med       Date:  2002-07       Impact factor: 5.721

10.  Diagnosis and management of ectopic pregnancy.

Authors:  Vanitha N Sivalingam; W Colin Duncan; Emma Kirk; Lucy A Shephard; Andrew W Horne
Journal:  J Fam Plann Reprod Health Care       Date:  2011-07-04
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  7 in total

1.  Red blood cell salvage analysis from clotted blood.

Authors:  Ethan K Craig; Mark H Yazer; Jonathan H Waters
Journal:  Blood Transfus       Date:  2018-04-04       Impact factor: 3.443

2.  Pregnancy in a non-communicating rudimentary horn of a unicornuate uterus.

Authors:  I M Cobec; P Seropian; A Rempen
Journal:  Hippokratia       Date:  2019 Apr-Jun       Impact factor: 0.471

3.  Ruptured ectopic pregnancy with a negative urine pregnancy test.

Authors:  Mallory Hughes; Andrew Lupo; Adrianne Browning
Journal:  Proc (Bayl Univ Med Cent)       Date:  2017-01

4.  Ectopic pregnancy until proven otherwise … even with a negative serum hCG test: A case report.

Authors:  Zachary A Kopelman; Erin A Keyser; Kelly J Morales
Journal:  Case Rep Womens Health       Date:  2021-01-27

5.  False negative point-of-care urine pregnancy tests in an urban academic emergency department: a retrospective cohort study.

Authors:  Sarah Kleinschmidt; Julianne N Dugas; Kerrie P Nelson; James A Feldman
Journal:  J Am Coll Emerg Physicians Open       Date:  2021-05-01

6.  Ectopic pregnancy and failed oocyte retrieval during in vitro fertilization stimulation: Two case reports.

Authors:  Wen-Jie Zhou; Bu-Fang Xu; Zhi-Hong Niu
Journal:  World J Clin Cases       Date:  2022-10-06       Impact factor: 1.534

7.  A Ruptured Ectopic Pregnancy Presenting with a Negative Urine Pregnancy Test.

Authors:  Johnathan Michael Sheele; Rachel Bernstein; Francis L Counselman
Journal:  Case Rep Emerg Med       Date:  2016-09-07
  7 in total

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