Literature DB >> 25694591

Expression of the novel hepatitis C virus core+1/ARF protein in the context of JFH1-based replicons.

Ioly Kotta-Loizou1, Ioannis Karakasiliotis1, Niki Vassilaki1, Panagiotis Sakellariou1, Ralf Bartenschlager2, Penelope Mavromara3.   

Abstract

Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25694591      PMCID： PMC4403472          DOI： 10.1128/JVI.02351-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

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7.  Expression studies of the core+1 protein of the hepatitis C virus 1a in mammalian cells. The influence of the core protein and proteasomes on the intracellular levels of core+1.

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3.  A Proteomic Approach to Study the Biological Role of Hepatitis C Virus Protein Core+1/ARFP.

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Review 5.  Hepatitis C Virus Translation Regulation.

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6.  A Novel Cis-Acting RNA Structural Element Embedded in the Core Coding Region of the Hepatitis C Virus Genome Directs Internal Translation Initiation of the Overlapping Core+1 ORF.

Authors:  Niki Vassilaki; Efseveia Frakolaki; Katerina I Kalliampakou; Panagiotis Sakellariou; Ioly Kotta-Loizou; Ralf Bartenschlager; Penelope Mavromara
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  6 in total

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