Literature DB >> 2569401

A novel CD3-J11d+ subset of CD4+CD8- cells repopulating thymus in radiation bone marrow chimeras.

K Matsumoto1, Y Yoshikai, G Matsuzaki, T Asano, K Nomoto.   

Abstract

Sequential appearance of T cell subpopulations occurs in the thymus of irradiated AKR (H-2k, Thy-1.1) mice at an early stage after transplantation with bone marrow cells of C3H/HeN (H-2k, Thy-1.2) mice. The donor-derived thymocytes were first detected on day 8 after bone marrow reconstitution. Although most of the thymocytes were CD4-CD8- cells, an appreciable level of CD4+CD8- cells was detected in the thymus at this stage. The early appearing CD4+CD8- cells were a novel subset of thymocytes that were J11d+CD3-. From day 10 to day 21 the proportion of CD4+CD8-CD3-J11d+ cells decreased while the proportion of CD4+CD8+ cells and CD4+CD8-CD3+J11d- cells increased. The CD4+CD8-CD3- cells seem to diversify to form CD4+CD8+ thymocytes after short-term culture in vitro. These results suggested the existence of a differential pathway from CD4-CD8- cells to CD4+CD8+ cells via CD4+CD8- cells in thymus.

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Year:  1989        PMID： 2569401     DOI： 10.1002/eji.1830190708

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  9 in total

1.  Effects of cyclosporin A on T-cell development in organ-cultured foetal thymus.

Authors:  Y Takeuchi; T Horiuchi; T Sugimoto; H Matsuda; H Yagita; K Okumura
Journal:  Immunology       Date:  1990-10       Impact factor: 7.397

2.  Clonal deletion of self-Mls-reactive thymocytes at the early stage in H-2-compatible but Mls-disparate radiation chimeras.

Authors:  M Ogimoto; Y Yoshikai; G Matsuzaki; S Ohga; K Matsumoto; K Nomoto
Journal:  Immunology       Date:  1990-03       Impact factor: 7.397

3.  Selective inhibition of immature CD4-CD8+ thymocyte proliferation, but not differentiation, by the thymus atrophy-inducing compound di-n-butyltin dichloride.

Authors:  R H Pieters; M Bol; T Ariëns; P Punt; W Seinen; N Bloksma; A H Penninks
Journal:  Immunology       Date:  1994-02       Impact factor: 7.397

4.  Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate.

Authors:  D L Kraft; I L Weissman; E K Waller
Journal:  J Exp Med       Date:  1993-07-01       Impact factor: 14.307

5.  Two differential pathways from double-negative to double-positive thymocytes.

Authors:  K Matsumoto; Y Yoshikai; Y Moroi; T Asano; T Ando; K Nomoto
Journal:  Immunology       Date:  1991-01       Impact factor: 7.397

6.  Lymphocytes with a CD4+ CD8- CD3- phenotype are effectors of experimental cutaneous graft-versus-host disease.

Authors:  H Sakamoto; J Michaelson; W K Jones; A K Bhan; S Abhyankar; M Silverstein; D E Golan; S J Burakoff; J L Ferrara
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

7.  Defect in negative selection in lpr donor-derived T cells differentiating in non-lpr host thymus.

Authors:  K Matsumoto; Y Yoshikai; T Asano; K Himeno; A Iwasaki; K Nomoto
Journal:  J Exp Med       Date:  1991-01-01       Impact factor: 14.307

8.  Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

Authors:  H T Petrie; P Hugo; R Scollay; K Shortman
Journal:  J Exp Med       Date:  1990-12-01       Impact factor: 14.307

9.  Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development.

Authors:  A Galy; S Verma; A Bárcena; H Spits
Journal:  J Exp Med       Date:  1993-08-01       Impact factor: 14.307
  9 in total

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