Literature DB >> 2569368

Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level.

J C Pedersen1, K Berg.   

Abstract

Subjects drawn from a population-based register were studied with respect to lipid level association. The association of isoforms of apolipoprotein E (apoE) with lipid level in the general population was found to be limited to people with one particular genotype at the low density lipoprotein receptor (LDLR) locus. The results presented in this paper suggest that functional LDLR variants enhance or limit the effect of isoforms of apoE. The association between apoE4 and serum total and LDL cholesterol level may be mediated through the LDL (apoB100, apoE) receptor to a greater extent than previously thought.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2569368     DOI： 10.1111/j.1399-0004.1989.tb02953.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  9 in total

Review 1.  Dissecting the genetic contribution to coronary heart disease.

Authors:  J W MacCluer; C M Kammerer
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

Review 2.  Metabolic syndrome components in murine models.

Authors:  Heather A Lawson; James M Cheverud
Journal:  Endocr Metab Immune Disord Drug Targets       Date:  2010-03       Impact factor: 2.895

3.  European workshop on LDL receptor defects. European Working Group on Familial Hypercholesterolaemia.

Authors:  H Schuster; S Humphries
Journal:  Clin Investig       Date:  1994-11

4.  The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances.

Authors:  S L Reilly; R E Ferrell; B A Kottke; M I Kamboh; C F Sing
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

5.  Shadows of complexity: what biological networks reveal about epistasis and pleiotropy.

Authors:  Anna L Tyler; Folkert W Asselbergs; Scott M Williams; Jason H Moore
Journal:  Bioessays       Date:  2009-02       Impact factor: 4.345

6.  The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study.

Authors:  P de Knijff; D I Boomsma; E de Wit; H J Kempen; J A Gevers Leuven; R R Frants; L M Havekes
Journal:  Hum Genet       Date:  1993-04       Impact factor: 4.132

7.  ApoE polymorphism in a small Mediterranean island: relationships with plasma lipids, lipoproteins and LDL particle size.

Authors:  C M Barbagallo; F Polizzi; M Severino; M Rizzo; N Vivona; F Onorato; R Caldarella; A B Cefalù; D Noto; A Notarbartolo; M R Averna
Journal:  Eur J Epidemiol       Date:  2001       Impact factor: 8.082

8.  Phenotypic heterogeneity associated with defective apolipoprotein B-100 and occurrence of the familial hypercholesterolemia phenotype in the absence of an LDL-receptor defect within a Canadian kindred.

Authors:  J Davignon; R Dufour; M Roy; C Bétard; Y Ma; S Ouellette; L Boulet; S Lussier-Cacan
Journal:  Eur J Epidemiol       Date:  1992-05       Impact factor: 8.082

9.  The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.

Authors:  Lucy Liu; Kevin R MacKenzie; Nagireddy Putluri; Mirjana Maletić-Savatić; Hugo J Bellen
Journal:  Cell Metab       Date:  2017-09-28       Impact factor: 27.287
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.