Iván Roa1, Xabier de Aretxabala. 1. aCreative Bioscience bDepartamento de Cirugía, Clínica Alemana, Santiago, Chile.
Abstract
PURPOSE OF REVIEW: Gallbladder cancer (GBC) should be considered an orphan disease in oncology and represent a unique carcinogenetic model. This review will analyse some of the current aspects of GBC. RECENT FINDINGS: Chile has the highest incidence and mortality of GBC in the world. Most patients are diagnosed in advanced stages with few treatment options. During the last two decades, little progress has been made in early diagnosis and treatment. At the molecular level, recent access to next-generation sequencing and other techniques for detecting the mutations of multiple genes have made advances in this area. SUMMARY: The use of therapies targeted according to the detection of specific molecular alterations is in the early stages of evaluation and could represent a significant advance in the treatment of a large number of patients from developing countries.
PURPOSE OF REVIEW: Gallbladder cancer (GBC) should be considered an orphan disease in oncology and represent a unique carcinogenetic model. This review will analyse some of the current aspects of GBC. RECENT FINDINGS: Chile has the highest incidence and mortality of GBC in the world. Most patients are diagnosed in advanced stages with few treatment options. During the last two decades, little progress has been made in early diagnosis and treatment. At the molecular level, recent access to next-generation sequencing and other techniques for detecting the mutations of multiple genes have made advances in this area. SUMMARY: The use of therapies targeted according to the detection of specific molecular alterations is in the early stages of evaluation and could represent a significant advance in the treatment of a large number of patients from developing countries.
Authors: Paula Fluxá; Daniel Rojas-Sepúlveda; María Alejandra Gleisner; Andrés Tittarelli; Pablo Villegas; Loreto Tapia; María Teresa Rivera; Mercedes Natalia López; Felipe Catán; Mario Uribe; Flavio Salazar-Onfray Journal: BMC Cancer Date: 2018-03-02 Impact factor: 4.430
Authors: Daniel Rojas-Sepúlveda; Andrés Tittarelli; María Alejandra Gleisner; Ignacio Ávalos; Cristián Pereda; Iván Gallegos; Fermín Eduardo González; Mercedes Natalia López; Jean Michel Butte; Juan Carlos Roa; Paula Fluxá; Flavio Salazar-Onfray Journal: Cancer Immunol Immunother Date: 2018-03-29 Impact factor: 6.968
Authors: Mohammed Yousef Aldossary; Abdullah Saleh AlQattan; Yasmeen Megad Alghamdi; Amal A Alayed; Fatimah Alquraish; Omar Abdulaziz AlAnzi; Nawaf Alabdulrahim; Abdulaziz Alateeq; Mohammed Saad Alqahtani Journal: Int J Surg Case Rep Date: 2019-10-29